TY - JOUR
T1 - Gastroprotection of calein D against ethanol-induced gastric lesions in mice
T2 - Role of prostaglandins, nitric oxide and sulfhydryls
AU - Sánchez-Mendoza, María Elena
AU - López-Lorenzo, Yaraset
AU - Cruz-Antonio, Leticia
AU - Matus-Meza, Audifás Salvador
AU - Sánchez-Mendoza, Yolanda
AU - Arrieta, Jesús
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019/2/11
Y1 - 2019/2/11
N2 - Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.
AB - Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.
KW - Calea urticifolia
KW - Calein D
KW - Gastric ulcer
KW - Gastroprotection
KW - Sesquiterpene lactones
UR - http://www.scopus.com/inward/record.url?scp=85061448293&partnerID=8YFLogxK
U2 - 10.3390/molecules24030622
DO - 10.3390/molecules24030622
M3 - Artículo
C2 - 30754621
AN - SCOPUS:85061448293
SN - 1420-3049
VL - 24
JO - Molecules
JF - Molecules
IS - 3
M1 - 622
ER -