Gastroprotection of calein D against ethanol-induced gastric lesions in mice: Role of prostaglandins, nitric oxide and sulfhydryls

María Elena Sánchez-Mendoza, Yaraset López-Lorenzo, Leticia Cruz-Antonio, Audifás Salvador Matus-Meza, Yolanda Sánchez-Mendoza, Jesús Arrieta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.

Original languageEnglish
Article number622
JournalMolecules
Volume24
Issue number3
DOIs
StatePublished - 11 Feb 2019

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prostaglandins
NG-Nitroarginine Methyl Ester
nitric oxide
lesions
Prostaglandins
mice
Stomach
Nitric Oxide
drugs
ethyl alcohol
Ethanol
Carbenoxolone
ulcers
Ethylmaleimide
Sesquiterpenes
Lactones
Peptic Ulcer
musculoskeletal system
Sulfhydryl Compounds
Skeleton

Keywords

  • Calea urticifolia
  • Calein D
  • Gastric ulcer
  • Gastroprotection
  • Sesquiterpene lactones

Cite this

Sánchez-Mendoza, María Elena ; López-Lorenzo, Yaraset ; Cruz-Antonio, Leticia ; Matus-Meza, Audifás Salvador ; Sánchez-Mendoza, Yolanda ; Arrieta, Jesús. / Gastroprotection of calein D against ethanol-induced gastric lesions in mice: Role of prostaglandins, nitric oxide and sulfhydryls. In: Molecules. 2019 ; Vol. 24, No. 3.
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Gastroprotection of calein D against ethanol-induced gastric lesions in mice: Role of prostaglandins, nitric oxide and sulfhydryls. / Sánchez-Mendoza, María Elena; López-Lorenzo, Yaraset; Cruz-Antonio, Leticia; Matus-Meza, Audifás Salvador; Sánchez-Mendoza, Yolanda; Arrieta, Jesús.

In: Molecules, Vol. 24, No. 3, 622, 11.02.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gastroprotection of calein D against ethanol-induced gastric lesions in mice: Role of prostaglandins, nitric oxide and sulfhydryls

AU - Sánchez-Mendoza, María Elena

AU - López-Lorenzo, Yaraset

AU - Cruz-Antonio, Leticia

AU - Matus-Meza, Audifás Salvador

AU - Sánchez-Mendoza, Yolanda

AU - Arrieta, Jesús

PY - 2019/2/11

Y1 - 2019/2/11

N2 - Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.

AB - Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.

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