TY - JOUR
T1 - Garlic (Allium sativum L.)
T2 - A brief review of its antigenotoxic effects
AU - Morales-González, José Antonio
AU - Madrigal-Bujaidar, Eduardo
AU - Sánchez-Gutiérrez, Manuel
AU - Izquierdo-Vega, Jeannett A.
AU - Carmen Valadez-Vega, María Del
AU - Álvarez-González, Isela
AU - Morales-González, Ángel
AU - Madrigal-Santillán, Eduardo
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019
Y1 - 2019
N2 - Traditional Medicine/Complementary and Alternative Medicine is a practice that incorporates medicine based on plants, animals, and minerals for diagnosing, treating, and preventing certain diseases, including chronic degenerative diseases such as obesity, diabetes, hypertension, atherosclerosis, and cancer. Different factors generate its continued acceptance, highlighting its diversity, easy access, low cost, and the presence of relatively few adverse effects and, importantly, a high possibility of discovering antigenotoxic agents. In this regard, it is known that the use of different antigenotoxic agents is an efficient alternative to preventing human cancer and that, in general, these can act by means of a combination of various mechanisms of action and against one or various mutagens and/or carcinogens. Therefore, it is relevant to confirm its usefulness, efficacy, and its spectrum of action through different assays. With this in mind, the present manuscript has as its objective the compilation of different investigations carried out with garlic that have demonstrated its genoprotective capacity, and that have been evaluated by means of five of the most outstanding tests (Ames test, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay). Thus, we intend to provide information and bibliographic support to investigators in order for them to broaden their studies on the antigenotoxic spectrum of action of this perennial plant.
AB - Traditional Medicine/Complementary and Alternative Medicine is a practice that incorporates medicine based on plants, animals, and minerals for diagnosing, treating, and preventing certain diseases, including chronic degenerative diseases such as obesity, diabetes, hypertension, atherosclerosis, and cancer. Different factors generate its continued acceptance, highlighting its diversity, easy access, low cost, and the presence of relatively few adverse effects and, importantly, a high possibility of discovering antigenotoxic agents. In this regard, it is known that the use of different antigenotoxic agents is an efficient alternative to preventing human cancer and that, in general, these can act by means of a combination of various mechanisms of action and against one or various mutagens and/or carcinogens. Therefore, it is relevant to confirm its usefulness, efficacy, and its spectrum of action through different assays. With this in mind, the present manuscript has as its objective the compilation of different investigations carried out with garlic that have demonstrated its genoprotective capacity, and that have been evaluated by means of five of the most outstanding tests (Ames test, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay). Thus, we intend to provide information and bibliographic support to investigators in order for them to broaden their studies on the antigenotoxic spectrum of action of this perennial plant.
KW - Ames test
KW - Antigenotoxic potential
KW - Chromosomal aberrations
KW - Comet assay
KW - Garlic
KW - Micronucleus
KW - Sister chromatid exchange
UR - http://www.scopus.com/inward/record.url?scp=85070891657&partnerID=8YFLogxK
U2 - 10.3390/foods8080343
DO - 10.3390/foods8080343
M3 - Artículo de revisión
C2 - 31412555
AN - SCOPUS:85070891657
SN - 2304-8158
VL - 8
JO - Foods
JF - Foods
IS - 8
M1 - 343
ER -