TY - JOUR
T1 - Features of oxidative and nitrosative metabolism in lung diseases
AU - Soodaeva, Svetlana
AU - Kubysheva, Nailya
AU - Klimanov, Igor
AU - Nikitina, Lidiya
AU - Batyrshin, Ildar
N1 - Publisher Copyright:
© 2019 Svetlana Soodaeva et al.
PY - 2019
Y1 - 2019
N2 - Respiratory diseases are accompanied by intensification of free radical processes at different levels of the biological body organization. Simultaneous stress and suppression of various parts of antioxidant protection lead to the development of oxidative stress (OS) and nitrosative stress (NS). The basic mechanisms of initiation and development of the OS and NS in pulmonary pathology are considered. The antioxidant defense system of the respiratory tract is characterized. The results of the NS and OS marker study in various respiratory diseases are presented. It is shown that NS and OS are multilevel complex-regulated processes, existing and developing in inseparable connection with a number of physiological and pathophysiological processes. The study of NS and OS mechanisms contributes to the improvement of the quality of diagnosis and the development of therapeutic agents that act on different pathogenetic stages of the disease.
AB - Respiratory diseases are accompanied by intensification of free radical processes at different levels of the biological body organization. Simultaneous stress and suppression of various parts of antioxidant protection lead to the development of oxidative stress (OS) and nitrosative stress (NS). The basic mechanisms of initiation and development of the OS and NS in pulmonary pathology are considered. The antioxidant defense system of the respiratory tract is characterized. The results of the NS and OS marker study in various respiratory diseases are presented. It is shown that NS and OS are multilevel complex-regulated processes, existing and developing in inseparable connection with a number of physiological and pathophysiological processes. The study of NS and OS mechanisms contributes to the improvement of the quality of diagnosis and the development of therapeutic agents that act on different pathogenetic stages of the disease.
UR - http://www.scopus.com/inward/record.url?scp=85066926130&partnerID=8YFLogxK
U2 - 10.1155/2019/1689861
DO - 10.1155/2019/1689861
M3 - Artículo de revisión
C2 - 31249640
AN - SCOPUS:85066926130
SN - 1942-0900
VL - 2019
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 1689861
ER -