TY - JOUR
T1 - Expression of cytokine mRNA in lymphocytes of malnourished children
AU - González-Martínez, Haydeé
AU - Rodríguez, Leonor
AU - Nájera, Oralia
AU - Cruz, David
AU - Miliar, Angel
AU - Domínguez, Aarón
AU - Sánchez, Fausto
AU - Graniel, Jaime
AU - González-Torres, María Cristina
N1 - Funding Information:
Acknowledgments This study was partially supported by PROMEP (grant UAM-I-CA-12), by CONACyT Mexico (grant 176371 for Haydeé González Martínez), and by Fondo de Formación de Doctores of CONACYT México (Haydeé González Martínez).
PY - 2008/9
Y1 - 2008/9
N2 - Introduction: Protein-calorie malnutrition represents a significant worldwide health problem and is associated with an increased risk for infections. The purpose of this study was to evaluate possible changes in type 1/type 2 responses balance in malnourished children. Results: The data obtained in the present study showed that the expression levels of tumor necrosis factor-α, interleukin (IL)-4, and IL-10 were more highly, in contrast IL-2, gamma interferon, and IL-6 genes were expressed less in all groups of malnourished children compared with the well-nourished infected children. It is important to indicate that the data collected in the present work agree with the results obtained by different authors, who showed differences in the production of cytokines in malnourished children. Conclusion: In conclusion, the results suggest that alterations in the balance of type 1/type 2 immune responses exist in malnourished children, and this could be the reason that the immunological system of the malnourished children is incapable of eradicating infections.
AB - Introduction: Protein-calorie malnutrition represents a significant worldwide health problem and is associated with an increased risk for infections. The purpose of this study was to evaluate possible changes in type 1/type 2 responses balance in malnourished children. Results: The data obtained in the present study showed that the expression levels of tumor necrosis factor-α, interleukin (IL)-4, and IL-10 were more highly, in contrast IL-2, gamma interferon, and IL-6 genes were expressed less in all groups of malnourished children compared with the well-nourished infected children. It is important to indicate that the data collected in the present work agree with the results obtained by different authors, who showed differences in the production of cytokines in malnourished children. Conclusion: In conclusion, the results suggest that alterations in the balance of type 1/type 2 immune responses exist in malnourished children, and this could be the reason that the immunological system of the malnourished children is incapable of eradicating infections.
KW - Cytokines
KW - Immunological responses type 1/type 2
KW - Lymphocytes
KW - Protein-calorie malnutrition
UR - http://www.scopus.com/inward/record.url?scp=51349114095&partnerID=8YFLogxK
U2 - 10.1007/s10875-008-9204-5
DO - 10.1007/s10875-008-9204-5
M3 - Artículo
C2 - 18496743
SN - 0271-9142
VL - 28
SP - 593
EP - 599
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
IS - 5
ER -