Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection

Armando Herrera-Arellano, Enrique Jiménez-Ferrer, Alejandro Zamilpa, María De Los Angeles Martínez-Rivera, Aída Verónica Rodríguez-Tovar, Sara Herrera-Alvarez, María Luisa Salas-Andonaegui, María Yemina Nava-Xalpa, Ansberto Méndez-Salas, Jaime Tortoriello

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Abstract

Mexican traditional medicine uses Solanum chrysotrichum to treat fungi-associated dermal and mucosal illness; its methanolic extract is active against dermatophytes and yeasts. Different spirostanic saponins (SC-2 - SC-6) were identified as the active molecules; SC-2 was the most active in demonstrating a fungicidal effect against Candida albicans and non-albicans strains. The aim of the present study was to compare the clinical (elimination of signs and symptoms) and mycological effectiveness (negative mycological studies) of an S. chrysotrichum herbal medicinal product (Sc-hmp), standardized in 1.89 mg of SC-2, against ketoconazole (400 mg) in the topical treatment of cervical and/or vaginal infection by Candida. Both treatments (vaginal suppositories) were administered daily during 7 continuous nights. The study included 101 women (49 in the experimental group) with a confirmed clinical condition and positivemycological studies (direct examination and/or culture) of Candida infection. Basal conditions did not show differences between the groups; a moderate clinical picture was present in 62% of the cases, direct examination was positive in 69%, and the culture was positive with C. albicans predominating (65%). At the end of the administration period, both treatments demonstrated 100% tolerability, and clinical cure in 57.14% of S. chrysotrichum-treated cases and in 72.5% of ketoconazole-treated cases (p = 0.16), as well as 62.8% and 97.5% of mycological effectiveness, respectively (p = 0.0 001). We conclude that, at the doses used, Sc-hmp exhibits the same clinical effectiveness as ketoconazole, but with lower percentages of mycological eradication. Additional clinical studies with Sc-hmp are necessary, with increasing doses of SC-2, for improving the clinical and mycological effectiveness. © Georg Thieme Verlag KG Stuttgart.
Original languageAmerican English
Pages (from-to)466-471
Number of pages418
JournalPlanta Medica
DOIs
StatePublished - 1 Apr 2009

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Solanum
Ketoconazole
Candida
Yeast
Yeasts
Candida albicans
Infection
Suppositories
Arthrodermataceae
Saponins
Traditional Medicine
Fungi
Signs and Symptoms
Medicine
Therapeutics
Skin
Molecules

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Herrera-Arellano, Armando ; Jiménez-Ferrer, Enrique ; Zamilpa, Alejandro ; Martínez-Rivera, María De Los Angeles ; Rodríguez-Tovar, Aída Verónica ; Herrera-Alvarez, Sara ; Salas-Andonaegui, María Luisa ; Nava-Xalpa, María Yemina ; Méndez-Salas, Ansberto ; Tortoriello, Jaime. / Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection. In: Planta Medica. 2009 ; pp. 466-471.
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title = "Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection",
abstract = "Mexican traditional medicine uses Solanum chrysotrichum to treat fungi-associated dermal and mucosal illness; its methanolic extract is active against dermatophytes and yeasts. Different spirostanic saponins (SC-2 - SC-6) were identified as the active molecules; SC-2 was the most active in demonstrating a fungicidal effect against Candida albicans and non-albicans strains. The aim of the present study was to compare the clinical (elimination of signs and symptoms) and mycological effectiveness (negative mycological studies) of an S. chrysotrichum herbal medicinal product (Sc-hmp), standardized in 1.89 mg of SC-2, against ketoconazole (400 mg) in the topical treatment of cervical and/or vaginal infection by Candida. Both treatments (vaginal suppositories) were administered daily during 7 continuous nights. The study included 101 women (49 in the experimental group) with a confirmed clinical condition and positivemycological studies (direct examination and/or culture) of Candida infection. Basal conditions did not show differences between the groups; a moderate clinical picture was present in 62{\%} of the cases, direct examination was positive in 69{\%}, and the culture was positive with C. albicans predominating (65{\%}). At the end of the administration period, both treatments demonstrated 100{\%} tolerability, and clinical cure in 57.14{\%} of S. chrysotrichum-treated cases and in 72.5{\%} of ketoconazole-treated cases (p = 0.16), as well as 62.8{\%} and 97.5{\%} of mycological effectiveness, respectively (p = 0.0 001). We conclude that, at the doses used, Sc-hmp exhibits the same clinical effectiveness as ketoconazole, but with lower percentages of mycological eradication. Additional clinical studies with Sc-hmp are necessary, with increasing doses of SC-2, for improving the clinical and mycological effectiveness. {\circledC} Georg Thieme Verlag KG Stuttgart.",
author = "Armando Herrera-Arellano and Enrique Jim{\'e}nez-Ferrer and Alejandro Zamilpa and Mart{\'i}nez-Rivera, {Mar{\'i}a De Los Angeles} and Rodr{\'i}guez-Tovar, {A{\'i}da Ver{\'o}nica} and Sara Herrera-Alvarez and Salas-Andonaegui, {Mar{\'i}a Luisa} and Nava-Xalpa, {Mar{\'i}a Yemina} and Ansberto M{\'e}ndez-Salas and Jaime Tortoriello",
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Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection. / Herrera-Arellano, Armando; Jiménez-Ferrer, Enrique; Zamilpa, Alejandro; Martínez-Rivera, María De Los Angeles; Rodríguez-Tovar, Aída Verónica; Herrera-Alvarez, Sara; Salas-Andonaegui, María Luisa; Nava-Xalpa, María Yemina; Méndez-Salas, Ansberto; Tortoriello, Jaime.

In: Planta Medica, 01.04.2009, p. 466-471.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection

AU - Herrera-Arellano, Armando

AU - Jiménez-Ferrer, Enrique

AU - Zamilpa, Alejandro

AU - Martínez-Rivera, María De Los Angeles

AU - Rodríguez-Tovar, Aída Verónica

AU - Herrera-Alvarez, Sara

AU - Salas-Andonaegui, María Luisa

AU - Nava-Xalpa, María Yemina

AU - Méndez-Salas, Ansberto

AU - Tortoriello, Jaime

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Mexican traditional medicine uses Solanum chrysotrichum to treat fungi-associated dermal and mucosal illness; its methanolic extract is active against dermatophytes and yeasts. Different spirostanic saponins (SC-2 - SC-6) were identified as the active molecules; SC-2 was the most active in demonstrating a fungicidal effect against Candida albicans and non-albicans strains. The aim of the present study was to compare the clinical (elimination of signs and symptoms) and mycological effectiveness (negative mycological studies) of an S. chrysotrichum herbal medicinal product (Sc-hmp), standardized in 1.89 mg of SC-2, against ketoconazole (400 mg) in the topical treatment of cervical and/or vaginal infection by Candida. Both treatments (vaginal suppositories) were administered daily during 7 continuous nights. The study included 101 women (49 in the experimental group) with a confirmed clinical condition and positivemycological studies (direct examination and/or culture) of Candida infection. Basal conditions did not show differences between the groups; a moderate clinical picture was present in 62% of the cases, direct examination was positive in 69%, and the culture was positive with C. albicans predominating (65%). At the end of the administration period, both treatments demonstrated 100% tolerability, and clinical cure in 57.14% of S. chrysotrichum-treated cases and in 72.5% of ketoconazole-treated cases (p = 0.16), as well as 62.8% and 97.5% of mycological effectiveness, respectively (p = 0.0 001). We conclude that, at the doses used, Sc-hmp exhibits the same clinical effectiveness as ketoconazole, but with lower percentages of mycological eradication. Additional clinical studies with Sc-hmp are necessary, with increasing doses of SC-2, for improving the clinical and mycological effectiveness. © Georg Thieme Verlag KG Stuttgart.

AB - Mexican traditional medicine uses Solanum chrysotrichum to treat fungi-associated dermal and mucosal illness; its methanolic extract is active against dermatophytes and yeasts. Different spirostanic saponins (SC-2 - SC-6) were identified as the active molecules; SC-2 was the most active in demonstrating a fungicidal effect against Candida albicans and non-albicans strains. The aim of the present study was to compare the clinical (elimination of signs and symptoms) and mycological effectiveness (negative mycological studies) of an S. chrysotrichum herbal medicinal product (Sc-hmp), standardized in 1.89 mg of SC-2, against ketoconazole (400 mg) in the topical treatment of cervical and/or vaginal infection by Candida. Both treatments (vaginal suppositories) were administered daily during 7 continuous nights. The study included 101 women (49 in the experimental group) with a confirmed clinical condition and positivemycological studies (direct examination and/or culture) of Candida infection. Basal conditions did not show differences between the groups; a moderate clinical picture was present in 62% of the cases, direct examination was positive in 69%, and the culture was positive with C. albicans predominating (65%). At the end of the administration period, both treatments demonstrated 100% tolerability, and clinical cure in 57.14% of S. chrysotrichum-treated cases and in 72.5% of ketoconazole-treated cases (p = 0.16), as well as 62.8% and 97.5% of mycological effectiveness, respectively (p = 0.0 001). We conclude that, at the doses used, Sc-hmp exhibits the same clinical effectiveness as ketoconazole, but with lower percentages of mycological eradication. Additional clinical studies with Sc-hmp are necessary, with increasing doses of SC-2, for improving the clinical and mycological effectiveness. © Georg Thieme Verlag KG Stuttgart.

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