TY - JOUR
T1 - Evaluation of the interaction between tramadol and diclofenac in several models of nociception in the rat
AU - Rodríguez-Silverio, Juan
AU - Déciga-Campos, Myrna
AU - Reyes-García, Gerardo
AU - Carrasco-Portugal, Miriam Del Carmen
AU - Flores-Murrieta, Francisco J.
PY - 2011/8
Y1 - 2011/8
N2 - Diclofenac and tramadol are drugs widely used for the treatment of pain. However, side effects may limit their use. As both drugs produce side effects that are dose-dependent, it seems appropriate to combine them in order to reduce the requirements for efficacy and, consequently, side effects. The purpose of this study was to evaluate the possible synergistic effect of these drugs in three experimental models of nociception in the rat. Dose-response curves for diclofenac and tramadol were constructed in three models, thermal hyperalgesia, formalin, and hot plate. From these curves, ED40 or ED30 (according to the model employed) values were obtained and isobolographic analyses were carried out based on 0.5:0.5 proportions. Synergistic interactions were observed in the thermal hyperalgesia and hot plate models and an additive interaction was obtained in the formalin test. These results suggest a good therapeutic potential of this combination in the treatment of pain.
AB - Diclofenac and tramadol are drugs widely used for the treatment of pain. However, side effects may limit their use. As both drugs produce side effects that are dose-dependent, it seems appropriate to combine them in order to reduce the requirements for efficacy and, consequently, side effects. The purpose of this study was to evaluate the possible synergistic effect of these drugs in three experimental models of nociception in the rat. Dose-response curves for diclofenac and tramadol were constructed in three models, thermal hyperalgesia, formalin, and hot plate. From these curves, ED40 or ED30 (according to the model employed) values were obtained and isobolographic analyses were carried out based on 0.5:0.5 proportions. Synergistic interactions were observed in the thermal hyperalgesia and hot plate models and an additive interaction was obtained in the formalin test. These results suggest a good therapeutic potential of this combination in the treatment of pain.
KW - diclofenac
KW - isobolographic analysis
KW - pain
KW - tramadol
UR - http://www.scopus.com/inward/record.url?scp=80052062108&partnerID=8YFLogxK
U2 - 10.1002/ddr.20440
DO - 10.1002/ddr.20440
M3 - Artículo
SN - 0272-4391
VL - 72
SP - 391
EP - 396
JO - Drug Development Research
JF - Drug Development Research
IS - 5
ER -