Evaluation of risk factors in the development of type 2 diabetes in a Mexican population

M. Martínez-Venegas, A. S. Valdez-Guerrero, J. C. Quintana-Pérez, A. F. Rubio-Guerra, L. Del Valle-Mondragon, J. L. Rodríguez-Bazan, F. Tamay-Cach, M. G. Arellano-Mendoza

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations

    Abstract

    Type 2 diabetes (T2D), which causes many adverse effects such as endothelial dysfunction and cardiovascular disease, affects approximately 425 million people worldwide. However, about half have not yet been diagnosed. For what is recommended the use of screening tools to identify individuals at risk for T2D or in the early stages of the disease in order to impement preventive strategies or early treatment. According to a widely used survey, the FINDRISC scale, a hereditary family history of T2D (FH-T2D) is as important a risk factor as having had high glucose levels. The aim of the present study was to carry out non-probabilistic sampling in a Mexican population to evaluate key factors in the development of diabetes. The participants were divided into three groups: with and without FH-T2D and diagnosed with T2D. A comparison of the groups with and without FH-T2D revealed higher values in the former for body mass index (BMI: 24.5 vs 21.9 kg/m2), glycosylated hemoglobin [Hb1Ac: 5.775% (39 mmol/mol) vs 4.825% (29 mmol/mol)] and triglycerides (164.18 vs 68.12 mg/dL), and a lower value for the BH4/BH2 index (0.7846 vs 1.6117). These results indicate significant metabolic alterations and endothelial dysfunction for the FH-T2D group. This strongly suggests the need to screen individuals with a family history of inherited T2D based on their level of HbA1c, triglycerides and BH4.

    Original languageEnglish
    Article number107784
    JournalDiabetes Research and Clinical Practice
    Volume155
    DOIs
    StatePublished - Sep 2019

    Keywords

    • BMI
    • Glycated hemoglobin
    • Risk factors
    • Tetrabiopterin
    • Triglycerides
    • Type 2 diabetes

    Fingerprint

    Dive into the research topics of 'Evaluation of risk factors in the development of type 2 diabetes in a Mexican population'. Together they form a unique fingerprint.

    Cite this