TY - JOUR
T1 - Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats
AU - Morales-Martínez, Adriana
AU - Sánchez-Mendoza, Alicia
AU - Martínez-Lazcano, Juan Carlos
AU - Pineda-Farías, Jorge Baruch
AU - Montes, Sergio
AU - El-Hafidi, Mohammed
AU - Martínez-Gopar, Pablo Eliasib
AU - Tristán-López, Luis
AU - Pérez-Neri, Iván
AU - Zamorano-Carrillo, Absalom
AU - Castro, Nelly
AU - Ríos, Camilo
AU - Pérez-Severiano, Francisca
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/8/9
Y1 - 2017/8/9
N2 - Essential fatty acids have an important effect on oxidative stress-related diseases. The Huntington's disease (HD) is a hereditary neurologic disorder in which oxidative stress caused by free radicals is an important damage mechanism. The HD experimental model induced by quinolinic acid (QUIN) has been widely used to evaluate therapeutic effects of antioxidant compounds. The aim of this study was to test whether the fatty acid content in olive- or fish-oil-rich diet prevents against QUIN-related oxidative damage in rats. Rats were fed during 20 days with an olive- or a fish-oil-rich diet (15% w/w). Posterior to diet period, rats were striatally microinjected with QUIN (240 nmol/µl) or saline solution. Then, we evaluated the neurological damage, oxidative status, and gamma isoform of the peroxisome proliferator-activated receptor (PPARγ) expression. Results showed that fatty acid-rich diet, mainly by fish oil, reduced circling behavior, prevented the fall in GABA levels, increased PPARγ expression, and prevented oxidative damage in striatal tissue. In addition none of the enriched diets exerted changes neither on triglycerides or cholesterol blood levels, nor or hepatic function. This study suggests that olive- and fish-oil-rich diets exert neuroprotective effects.
AB - Essential fatty acids have an important effect on oxidative stress-related diseases. The Huntington's disease (HD) is a hereditary neurologic disorder in which oxidative stress caused by free radicals is an important damage mechanism. The HD experimental model induced by quinolinic acid (QUIN) has been widely used to evaluate therapeutic effects of antioxidant compounds. The aim of this study was to test whether the fatty acid content in olive- or fish-oil-rich diet prevents against QUIN-related oxidative damage in rats. Rats were fed during 20 days with an olive- or a fish-oil-rich diet (15% w/w). Posterior to diet period, rats were striatally microinjected with QUIN (240 nmol/µl) or saline solution. Then, we evaluated the neurological damage, oxidative status, and gamma isoform of the peroxisome proliferator-activated receptor (PPARγ) expression. Results showed that fatty acid-rich diet, mainly by fish oil, reduced circling behavior, prevented the fall in GABA levels, increased PPARγ expression, and prevented oxidative damage in striatal tissue. In addition none of the enriched diets exerted changes neither on triglycerides or cholesterol blood levels, nor or hepatic function. This study suggests that olive- and fish-oil-rich diets exert neuroprotective effects.
KW - Essential fatty acids
KW - Fish oil
KW - Huntington's disease
KW - Olive oil
KW - Oxidative damage
UR - http://www.scopus.com/inward/record.url?scp=84978538751&partnerID=8YFLogxK
U2 - 10.1080/1028415X.2016.1147683
DO - 10.1080/1028415X.2016.1147683
M3 - Artículo
C2 - 26928375
SN - 1028-415X
VL - 20
SP - 388
EP - 395
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 7
ER -