TY - JOUR
T1 - (−)-Epicatechin modifies body composition of the male offspring of obese rats
AU - de los Santos, Sergio
AU - Coral-Vázquez, Ramón Mauricio
AU - Menjivar, Marta
AU - Granados-Silvestre, María de los Ángeles
AU - Tejeda, María Elena
AU - Reyes-Castro, Luis Antonio
AU - Méndez, Juan Pablo
AU - Zambrano, Elena
AU - Canto, Patricia
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/7
Y1 - 2019/7
N2 - The aim of our study was to determine if two protocols of (−)-epicatechin (Epi) (short and long) can modify fat, muscle and bone mass, in the male offspring of the maternal rat obesity model induced by high-fat diet (HFD). Four male offspring per group from different litters were randomly selected to the control or Epi intervention groups. We administered Epi twice daily/13 weeks (long) or for two weeks (short). The long Epi administration induced a significant decrease in the amount of total and visceral fat and an increased lean mass. Besides, short Epi administration increased whole body BMD of the male offspring of the control and maternal obesity groups. In conclusion, the administration of long Epi protocol elicited better results in decreasing total fat and all fat deposits and increased lean mass. However, only the short Epi protocol increased the total BMD in the male offspring.
AB - The aim of our study was to determine if two protocols of (−)-epicatechin (Epi) (short and long) can modify fat, muscle and bone mass, in the male offspring of the maternal rat obesity model induced by high-fat diet (HFD). Four male offspring per group from different litters were randomly selected to the control or Epi intervention groups. We administered Epi twice daily/13 weeks (long) or for two weeks (short). The long Epi administration induced a significant decrease in the amount of total and visceral fat and an increased lean mass. Besides, short Epi administration increased whole body BMD of the male offspring of the control and maternal obesity groups. In conclusion, the administration of long Epi protocol elicited better results in decreasing total fat and all fat deposits and increased lean mass. However, only the short Epi protocol increased the total BMD in the male offspring.
KW - (−)-Epicatechin
KW - Bone density
KW - Fat mass
KW - Male offspring
KW - Muscle mass
UR - http://www.scopus.com/inward/record.url?scp=85065650313&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2019.05.014
DO - 10.1016/j.jff.2019.05.014
M3 - Artículo
AN - SCOPUS:85065650313
SN - 1756-4646
VL - 58
SP - 367
EP - 373
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -