(−)-Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high-fat diet

Sergio De los Santos, Ramón Mauricio Coral-Vázquez, Marta Menjivar, María de los Ángeles Granados-Silvestre, Sebastián De la Rosa, Luis Antonio Reyes-Castro, Juan Pablo Méndez, Elena Zambrano, Patricia Canto

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Abstract

A combination of maternal obesity and high-fat diet (HFD) in offspring postnatal life has deleterious effects, and (−)-epicatechin (Epi) treatment can reverse these adverse effects. To investigate whether Epi administration can modify fat mass, muscle mass, and bone mass in male rats descended from obese mothers, fed postnatally on an HFD. Male offspring of mothers fed with control diet formed the control group (C), control group with high-fat diet (CHF), and control group with high-fat diet + epicatechin (CHF + Epi). Male offspring of maternal obesity formed the group with control diet (MO), maternal obesity group with high-fat diet (MOHF), and maternal obesity group with high-fat diet + epicatechin (MOHF + Epi). We measured total fat and weight of visceral adipose tissue by dissection and by dual-energy x-ray absorptiometry scanning body composition. Epicatechin diminished total and visceral pads fat of male offspring of CHF + Epi and MOHF + Epi groups versus to male offspring of CHF and MOHF groups. Besides, epicatechin increased lean mass in CHF + Epi and MOHF + Epi groups, but these changes were not significant. Total body mineral density of the male offspring of CHF, MOHF, and MOHF + Epi groups was significantly higher versus male offspring of C and MO groups. Obesity programming model plus a high-fat postnatal diet presents higher visceral adipose tissue, decreased lean mass, and modified body mineral density when compared with a direct obesity model and its controls. Epicatechin treatment improved body composition; however, it was not able to induce similar values as presented by the controls.

Original languageEnglish
JournalFundamental and Clinical Pharmacology
DOIs
StateAccepted/In press - 2022

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