Environmentally relevant concentrations of glibenclamide induce oxidative stress in common carp (Cyprinus carpio)

Ericka María Guadalupe Martínez-Viveros, Hariz Islas-Flores, Octavio Dublán-García, Marcela Galar-Martínez, Nely SanJuan-Reyes, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

© 2018 Elsevier Ltd The hypoglycemic pharmaceutical glibenclamide (GLB) is widely used around the world. This medication is released into the environment by municipal, hospital and industrial wastewater discharges. Although there are reports of its environmental occurrence in the scientific literature, toxicity studies on aquatic species of commercial interest such as the common carp Cyprinus carpio are scarce. The present study aimed to evaluate the oxidative stress induced on C. carpio by environmentally relevant concentrations of GLB. Biomarkers of oxidative damage such as hydroperoxide content, lipid peroxidation and protein carbonyl content were evaluated as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The concentration of GLB was determined in water as well as in gill, liver, muscle, brain and blood of carp at 12, 24, 48, 72 and 96 h. The findings obtained in the study prove that GLB induces increases in biomarkers of oxidative damage and antioxidant enzyme activity in the teleost C. carpio, that this response is not concentration dependent and that the organs evaluated bioconcentrate this hypoglycemic agent. These findings permit us to conclude that the presence of GLB in water bodies represents a risk for aquatic species.
Original languageAmerican English
Pages (from-to)105-116
Number of pages93
JournalChemosphere
DOIs
StatePublished - 1 Apr 2018

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Oxidative stress
Carps
Glyburide
Biomarkers
Antioxidants
antioxidant
biomarker
Oxidative Stress
damage
Enzyme activity
teleost
Liver
Drug products
Lipids
enzyme activity
Toxicity
Muscle
brain
Water
Brain

Cite this

Guadalupe Martínez-Viveros, Ericka María ; Islas-Flores, Hariz ; Dublán-García, Octavio ; Galar-Martínez, Marcela ; SanJuan-Reyes, Nely ; García-Medina, Sandra ; Hernández-Navarro, María Dolores ; Gómez-Oliván, Leobardo Manuel. / Environmentally relevant concentrations of glibenclamide induce oxidative stress in common carp (Cyprinus carpio). In: Chemosphere. 2018 ; pp. 105-116.
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abstract = "{\circledC} 2018 Elsevier Ltd The hypoglycemic pharmaceutical glibenclamide (GLB) is widely used around the world. This medication is released into the environment by municipal, hospital and industrial wastewater discharges. Although there are reports of its environmental occurrence in the scientific literature, toxicity studies on aquatic species of commercial interest such as the common carp Cyprinus carpio are scarce. The present study aimed to evaluate the oxidative stress induced on C. carpio by environmentally relevant concentrations of GLB. Biomarkers of oxidative damage such as hydroperoxide content, lipid peroxidation and protein carbonyl content were evaluated as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The concentration of GLB was determined in water as well as in gill, liver, muscle, brain and blood of carp at 12, 24, 48, 72 and 96 h. The findings obtained in the study prove that GLB induces increases in biomarkers of oxidative damage and antioxidant enzyme activity in the teleost C. carpio, that this response is not concentration dependent and that the organs evaluated bioconcentrate this hypoglycemic agent. These findings permit us to conclude that the presence of GLB in water bodies represents a risk for aquatic species.",
author = "{Guadalupe Mart{\'i}nez-Viveros}, {Ericka Mar{\'i}a} and Hariz Islas-Flores and Octavio Dubl{\'a}n-Garc{\'i}a and Marcela Galar-Mart{\'i}nez and Nely SanJuan-Reyes and Sandra Garc{\'i}a-Medina and Hern{\'a}ndez-Navarro, {Mar{\'i}a Dolores} and G{\'o}mez-Oliv{\'a}n, {Leobardo Manuel}",
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Guadalupe Martínez-Viveros, EM, Islas-Flores, H, Dublán-García, O, Galar-Martínez, M, SanJuan-Reyes, N, García-Medina, S, Hernández-Navarro, MD & Gómez-Oliván, LM 2018, 'Environmentally relevant concentrations of glibenclamide induce oxidative stress in common carp (Cyprinus carpio)', Chemosphere, pp. 105-116. https://doi.org/10.1016/j.chemosphere.2018.01.020

Environmentally relevant concentrations of glibenclamide induce oxidative stress in common carp (Cyprinus carpio). / Guadalupe Martínez-Viveros, Ericka María; Islas-Flores, Hariz; Dublán-García, Octavio; Galar-Martínez, Marcela; SanJuan-Reyes, Nely; García-Medina, Sandra; Hernández-Navarro, María Dolores; Gómez-Oliván, Leobardo Manuel.

In: Chemosphere, 01.04.2018, p. 105-116.

Research output: Contribution to journalArticle

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T1 - Environmentally relevant concentrations of glibenclamide induce oxidative stress in common carp (Cyprinus carpio)

AU - Guadalupe Martínez-Viveros, Ericka María

AU - Islas-Flores, Hariz

AU - Dublán-García, Octavio

AU - Galar-Martínez, Marcela

AU - SanJuan-Reyes, Nely

AU - García-Medina, Sandra

AU - Hernández-Navarro, María Dolores

AU - Gómez-Oliván, Leobardo Manuel

PY - 2018/4/1

Y1 - 2018/4/1

N2 - © 2018 Elsevier Ltd The hypoglycemic pharmaceutical glibenclamide (GLB) is widely used around the world. This medication is released into the environment by municipal, hospital and industrial wastewater discharges. Although there are reports of its environmental occurrence in the scientific literature, toxicity studies on aquatic species of commercial interest such as the common carp Cyprinus carpio are scarce. The present study aimed to evaluate the oxidative stress induced on C. carpio by environmentally relevant concentrations of GLB. Biomarkers of oxidative damage such as hydroperoxide content, lipid peroxidation and protein carbonyl content were evaluated as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The concentration of GLB was determined in water as well as in gill, liver, muscle, brain and blood of carp at 12, 24, 48, 72 and 96 h. The findings obtained in the study prove that GLB induces increases in biomarkers of oxidative damage and antioxidant enzyme activity in the teleost C. carpio, that this response is not concentration dependent and that the organs evaluated bioconcentrate this hypoglycemic agent. These findings permit us to conclude that the presence of GLB in water bodies represents a risk for aquatic species.

AB - © 2018 Elsevier Ltd The hypoglycemic pharmaceutical glibenclamide (GLB) is widely used around the world. This medication is released into the environment by municipal, hospital and industrial wastewater discharges. Although there are reports of its environmental occurrence in the scientific literature, toxicity studies on aquatic species of commercial interest such as the common carp Cyprinus carpio are scarce. The present study aimed to evaluate the oxidative stress induced on C. carpio by environmentally relevant concentrations of GLB. Biomarkers of oxidative damage such as hydroperoxide content, lipid peroxidation and protein carbonyl content were evaluated as well as the activity of the antioxidant enzymes superoxide dismutase and catalase. The concentration of GLB was determined in water as well as in gill, liver, muscle, brain and blood of carp at 12, 24, 48, 72 and 96 h. The findings obtained in the study prove that GLB induces increases in biomarkers of oxidative damage and antioxidant enzyme activity in the teleost C. carpio, that this response is not concentration dependent and that the organs evaluated bioconcentrate this hypoglycemic agent. These findings permit us to conclude that the presence of GLB in water bodies represents a risk for aquatic species.

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