TY - JOUR
T1 - Escherichia coli enterotoxigénica y enteroagregativa
T2 - Prevalencia, patogénesis y modelos múridos
AU - Ríos-Muñiz, Diana
AU - Cerna-Cortés, Jorge Francisco
AU - Morán-García, Nadia
AU - Meza-Segura, Mario
AU - Estrada-García, Teresa
N1 - Publisher Copyright:
© 2019, (publisher Name). All right reserved.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Enterotoxigenic (ETEC) and enteroaggregative Escherichia coli (EAEC) pathotypes are important etiological agents causative of diarrhea in children younger than 5 years of age in Mexico and in developing countries, where they cause numerous deaths. Both have been associated with delayed growth in children and are the main causative agents of traveler’s diarrhea. The pathogenesis of both bacteria starts by adhering to the intestinal epithelium by means of fimbriae, called colonization factors in human ETEC isolates and aggregative adherence fimbriae in EAEC isolates. Once ETEC adheres to the enterocyte, it produces one or both of its toxins and induces the secretion of chloride and sodium ions and water into the intestinal lumen, producing its characteristic watery diarrhea. EAEC binds to the intestinal epithelium forming a biofilm, induces the production of mucus, releases its toxins and promotes inflammation. EAEC and ETEC infection models with wild-type C57BL/6 and CD40 ligand-deficient mice (with intact microbiota), respectively, revealed that undernutrition and low-zinc diet increases EAEC infection, causing growth retardation, and that ETEC colonizes, persists and induces local and systemic humoral immune response.
AB - Enterotoxigenic (ETEC) and enteroaggregative Escherichia coli (EAEC) pathotypes are important etiological agents causative of diarrhea in children younger than 5 years of age in Mexico and in developing countries, where they cause numerous deaths. Both have been associated with delayed growth in children and are the main causative agents of traveler’s diarrhea. The pathogenesis of both bacteria starts by adhering to the intestinal epithelium by means of fimbriae, called colonization factors in human ETEC isolates and aggregative adherence fimbriae in EAEC isolates. Once ETEC adheres to the enterocyte, it produces one or both of its toxins and induces the secretion of chloride and sodium ions and water into the intestinal lumen, producing its characteristic watery diarrhea. EAEC binds to the intestinal epithelium forming a biofilm, induces the production of mucus, releases its toxins and promotes inflammation. EAEC and ETEC infection models with wild-type C57BL/6 and CD40 ligand-deficient mice (with intact microbiota), respectively, revealed that undernutrition and low-zinc diet increases EAEC infection, causing growth retardation, and that ETEC colonizes, persists and induces local and systemic humoral immune response.
KW - Diarrhea in children
KW - Enteroaggregative Escherichia coli
KW - Enterotoxigenic Escherichia coli
KW - Murine models
KW - Undernutrition
UR - http://www.scopus.com/inward/record.url?scp=85071754464&partnerID=8YFLogxK
U2 - 10.24875/GMM.19004716
DO - 10.24875/GMM.19004716
M3 - Artículo
C2 - 31486791
AN - SCOPUS:85071754464
SN - 0016-3813
VL - 155
SP - 410
EP - 416
JO - Gaceta Medica de Mexico
JF - Gaceta Medica de Mexico
IS - 4
ER -