TY - JOUR
T1 - Efficient total synthesis of racemic bisabolane sesquiterpenes curcuphenol and xanthorrhizol starting from substituted acetophenones
AU - Montiel, Luisa E.
AU - Zepeda, L. Gerardo
AU - Tamariz, Joaquín
PY - 2010/7
Y1 - 2010/7
N2 - A total synthesis of natural bisabolane sesquiterpenes curcuphenol (1) and xanthorrhizol (2) was developed by using the substituted acetophenones 4 and 5, respectively, as starting materials. The acetyl group of the latter was activated through ethoxycarbonylation to carry out the prenylation, which was performed successfully to give their respective precursors 11a and 11b, and 21 that were converted into the corresponding natural sesquiterpenes 1 and 2, respectively, over four steps and in high overall yields.
AB - A total synthesis of natural bisabolane sesquiterpenes curcuphenol (1) and xanthorrhizol (2) was developed by using the substituted acetophenones 4 and 5, respectively, as starting materials. The acetyl group of the latter was activated through ethoxycarbonylation to carry out the prenylation, which was performed successfully to give their respective precursors 11a and 11b, and 21 that were converted into the corresponding natural sesquiterpenes 1 and 2, respectively, over four steps and in high overall yields.
UR - http://www.scopus.com/inward/record.url?scp=77954904221&partnerID=8YFLogxK
U2 - 10.1002/hlca.201000111
DO - 10.1002/hlca.201000111
M3 - Artículo
SN - 0018-019X
VL - 93
SP - 1261
EP - 1273
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 7
ER -