TY - JOUR
T1 - Efficacy and safety of the metformin-mazindol anorectic combination in rat
AU - Argüelles-Tello, Federico
AU - Roa-Coria, José Eduardo
AU - Zúñiga-Romero, Ángel
AU - Huerta-Cruz, Juan Carlos
AU - Quiñonez-Bastidas, Geovanna Nalley
AU - Flores-Murrieta, Francisco Javier
AU - Rocha-González, Héctor Isaac
AU - Reyes-García, Juan Gerardo
N1 - Publisher Copyright:
© 2021 Sciendo. All rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student´s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.
AB - The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED40t) did not differ from the experimental effective dose 40 (ED40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student´s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors.
KW - Anorectic interaction
KW - Anxiolysis
KW - Hypoglycemic effect
KW - Mazindol-metformin combination
UR - http://www.scopus.com/inward/record.url?scp=85095861711&partnerID=8YFLogxK
U2 - 10.2478/acph-2021-0019
DO - 10.2478/acph-2021-0019
M3 - Artículo
C2 - 33151165
AN - SCOPUS:85095861711
SN - 1330-0075
VL - 71
SP - 279
EP - 291
JO - Acta Pharmaceutica
JF - Acta Pharmaceutica
IS - 2
ER -