TY - JOUR
T1 - Effects of Selenium Nanoparticles Using Potential Natural Compounds Naringenin and Baicalin for Diabetes
AU - Gutiérrez, Rosa Martha Pérez
AU - Gómez, Julio Téllez
AU - Jerónimo, Felipe Fernando Martínez
AU - Paredes-Carrera, Silvia Patricia
AU - Sánchez-Ochoa, Jesús Carlos
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12/15
Y1 - 2023/12/15
N2 - Current investigation aimed to evaluate a formulation of selenium nanoparticles (SeNPs) using Naringenin/Baicalin in streptozotocin-induced diabetic mice and INS-1 pancreatic β-cells. Nanoparticles were characterized using Fourier Transform-infrared, ultra-violet-visible, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Zetasizer showing the existence of NAR/BAI on the surface of Se NPs. NAR/BAI/SeNPs have sizer ranging between 80 nm and 119 nm, showing a negative potential of-22.3 mV and a polydispersity index (PDI) of-0.249, indicating that they form a stable dispersion with stability within five months. The EE and LC flavonoids-loaded NPs were 80.1% and 25.4%, respectively. All parameter biochemical were altered by diabetic induction in mice; after 8 weeks of treatment, blood glucose, insulin levels, lipid profile, and glycosylated hemoglobin exhibited significant glucose and insulin effect in the oral glucose tolerance test, indicating improved insulin resistance. In the liver, NAR/BAI/SeNPs increase superoxide dismutase, Catalase glutathione peroxidase, as well as reduce lipid peroxidation, and transaminases aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities improved liver function elevating liver and muscle glycogen content, protects pancreatic b cells against high glucose-induced damage due to its synergistic effect between selenium with flavonoids. According to the results, NAR/BAI/SeNPs exhibit an anti-diabetic effect protecting and repairing pancreatic b cells.
AB - Current investigation aimed to evaluate a formulation of selenium nanoparticles (SeNPs) using Naringenin/Baicalin in streptozotocin-induced diabetic mice and INS-1 pancreatic β-cells. Nanoparticles were characterized using Fourier Transform-infrared, ultra-violet-visible, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Zetasizer showing the existence of NAR/BAI on the surface of Se NPs. NAR/BAI/SeNPs have sizer ranging between 80 nm and 119 nm, showing a negative potential of-22.3 mV and a polydispersity index (PDI) of-0.249, indicating that they form a stable dispersion with stability within five months. The EE and LC flavonoids-loaded NPs were 80.1% and 25.4%, respectively. All parameter biochemical were altered by diabetic induction in mice; after 8 weeks of treatment, blood glucose, insulin levels, lipid profile, and glycosylated hemoglobin exhibited significant glucose and insulin effect in the oral glucose tolerance test, indicating improved insulin resistance. In the liver, NAR/BAI/SeNPs increase superoxide dismutase, Catalase glutathione peroxidase, as well as reduce lipid peroxidation, and transaminases aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities improved liver function elevating liver and muscle glycogen content, protects pancreatic b cells against high glucose-induced damage due to its synergistic effect between selenium with flavonoids. According to the results, NAR/BAI/SeNPs exhibit an anti-diabetic effect protecting and repairing pancreatic b cells.
KW - antioxidant
KW - baicalin
KW - diabetes
KW - nanoparticles
KW - naringenin
KW - selenium
UR - http://www.scopus.com/inward/record.url?scp=85153080341&partnerID=8YFLogxK
U2 - 10.33263/BRIAC136.597
DO - 10.33263/BRIAC136.597
M3 - Artículo
AN - SCOPUS:85153080341
SN - 2069-5837
VL - 13
JO - Biointerface Research in Applied Chemistry
JF - Biointerface Research in Applied Chemistry
IS - 6
M1 - 597
ER -