TY - JOUR
T1 - Effectiveness of Photodynamic Therapy in Elimination of HPV-16 and HPV-18 Associated with CIN I in Mexican Women
AU - Maldonado Alvarado, Elizabeth
AU - Osorio Peralta, Martha Olivia
AU - Moreno Vázquez, Alejandra
AU - Martínez Guzmán, Lydia Alejandra
AU - Melo Petrone, Maria Eugenia
AU - Enriquez Mar, Zulma Iveth
AU - Jovel Galdamez, Dora Estela
AU - Carrión Solana, Bárbara
AU - Balderas Martínez, Guadalupe
AU - Parra, Eduarda
AU - Castellanos Oliveros, Rossana Inés
AU - Bello Leiva, Rosa Linda
AU - Espinosa Montesinos, Araceli
AU - Barrera Mendoza, Citlalli
AU - Medina García, Selma Eugenia
AU - Ramón Gallegos, Eva
N1 - Publisher Copyright:
© 2017 The American Society of Photobiology
PY - 2017/10
Y1 - 2017/10
N2 - This study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ-aminolevulinic acid (5-ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5-ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm−2 at 635 nm. This procedure was performed three times at 48-h intervals. Clinical follow-up was performed at 3, 6, and 12 months after the initial PDT administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of HPV-infected patients without evidence of CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. PDT using 6% 5-ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I.
AB - This study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ-aminolevulinic acid (5-ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5-ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm−2 at 635 nm. This procedure was performed three times at 48-h intervals. Clinical follow-up was performed at 3, 6, and 12 months after the initial PDT administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of HPV-infected patients without evidence of CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. PDT using 6% 5-ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I.
UR - http://www.scopus.com/inward/record.url?scp=85029593542&partnerID=8YFLogxK
U2 - 10.1111/php.12769
DO - 10.1111/php.12769
M3 - Artículo
C2 - 28380684
SN - 0031-8655
VL - 93
SP - 1269
EP - 1275
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
IS - 5
ER -