TY - JOUR
T1 - Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis
AU - Marquezan, Maria Carolina
AU - Nascimento, Heloisa
AU - Vieira, Luis Antonio
AU - Serapião, Myrna
AU - Ghanem, Ramon Coral
AU - Belfort, Rubens
AU - Freitas, Denise
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Purpose To evaluate topical tacrolimus ointment for treating Thygeson's superficial punctate keratitis (Thygeson SPK). Design Retrospective interventional case series. Methods setting: Institutional practice. patient population: The medical records of 14 patients (9 women; age range, 9-65 years) with Thygeson SPK were reviewed retrospectively. Diagnosis was based on the history and clinical examination. intervention: Patients were treated with tacrolimus 0.03% eye ointment instilled into the lower fornix twice daily for the first 2 weeks, followed by nocturnal application. The clinical signs and symptoms were assessed after 1 month of treatment. The drug was tapered with disease improvement. main outcome measure(s): Treatment efficacy and side effects. Results All patients had bilateral disease (average duration, 6 years). All patients, except 2 who used the medication irregularly, had improved visual acuity (VA), symptoms, and signs as long as the medication was applied. Before treatment 28.57% of patients had VA between 20/30 and 20/50, with improvement after treatment to 20/25 or 20/20. Attempts to withdraw the medication resulted in recurrent disease, and, therefore, treatment was not curative during the study period. No significant local medication side effects were reported. Conclusion Tacrolimus eye ointment 0.03% was effective for controlling Thygeson SPK for a long period with good patient tolerance and no noticeable local or systemic side effects. During the average 6-year follow-up, treatment was not curative. Randomized studies are difficult to conduct because of the disease rarity.
AB - Purpose To evaluate topical tacrolimus ointment for treating Thygeson's superficial punctate keratitis (Thygeson SPK). Design Retrospective interventional case series. Methods setting: Institutional practice. patient population: The medical records of 14 patients (9 women; age range, 9-65 years) with Thygeson SPK were reviewed retrospectively. Diagnosis was based on the history and clinical examination. intervention: Patients were treated with tacrolimus 0.03% eye ointment instilled into the lower fornix twice daily for the first 2 weeks, followed by nocturnal application. The clinical signs and symptoms were assessed after 1 month of treatment. The drug was tapered with disease improvement. main outcome measure(s): Treatment efficacy and side effects. Results All patients had bilateral disease (average duration, 6 years). All patients, except 2 who used the medication irregularly, had improved visual acuity (VA), symptoms, and signs as long as the medication was applied. Before treatment 28.57% of patients had VA between 20/30 and 20/50, with improvement after treatment to 20/25 or 20/20. Attempts to withdraw the medication resulted in recurrent disease, and, therefore, treatment was not curative during the study period. No significant local medication side effects were reported. Conclusion Tacrolimus eye ointment 0.03% was effective for controlling Thygeson SPK for a long period with good patient tolerance and no noticeable local or systemic side effects. During the average 6-year follow-up, treatment was not curative. Randomized studies are difficult to conduct because of the disease rarity.
UR - http://www.scopus.com/inward/record.url?scp=84941423535&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2015.06.019
DO - 10.1016/j.ajo.2015.06.019
M3 - Artículo
SN - 0002-9394
VL - 160
SP - 663
EP - 668
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -