TY - JOUR
T1 - Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico
AU - Solís-Martínez, Obed
AU - Plasa-Carvalho, Valentina
AU - Phillips-Sixtos, Geraldine
AU - Trujillo-Cabrera, Yanelly
AU - Hernández-Cuellar, Arturo
AU - Queipo-García, Gloria E.
AU - Meaney-Mendiolea, Eduardo
AU - Ceballos-Reyes, Guillermo M.
AU - Fuchs-Tarlovsky, Vanessa
N1 - Publisher Copyright:
© 2018 Taylor & Francis Group, LLC.
PY - 2018/5/19
Y1 - 2018/5/19
N2 - Introduction: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer. Materials and methods: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment. We assessed body composition by bioelectrical impedance analysis and determined IL-1β, IL-6, TNF-α and IFN-γ, CRP, serum proteins, and blood count at baseline and at the end of the study. Results: 32 patients received EPA (2 g/day) and 32 became controls. A decrease in serum levels of IL-1β, IL-6, TNF-α, and IFN-γ was observed in the experimental group, as well as regulation of body weight (−0.3 ± 5.9 vs. −2.1 ± 3.7), lean body mass (−0.2 ± 3.8 vs. −1.3 ± 3.6), body fat mass (0.2 ± 3.5 vs. −1.2 ± 3.8), and quality of life (10 ± 33 vs. 5 ± 34). Conclusion: Supplementing with 2 g/day of EPA to head and neck cancer patient during antineoplastic treatment regulates serum pro-inflammatory cytokines, body weight, lean body mass, and improve quality of life.
AB - Introduction: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer. Materials and methods: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment. We assessed body composition by bioelectrical impedance analysis and determined IL-1β, IL-6, TNF-α and IFN-γ, CRP, serum proteins, and blood count at baseline and at the end of the study. Results: 32 patients received EPA (2 g/day) and 32 became controls. A decrease in serum levels of IL-1β, IL-6, TNF-α, and IFN-γ was observed in the experimental group, as well as regulation of body weight (−0.3 ± 5.9 vs. −2.1 ± 3.7), lean body mass (−0.2 ± 3.8 vs. −1.3 ± 3.6), body fat mass (0.2 ± 3.5 vs. −1.2 ± 3.8), and quality of life (10 ± 33 vs. 5 ± 34). Conclusion: Supplementing with 2 g/day of EPA to head and neck cancer patient during antineoplastic treatment regulates serum pro-inflammatory cytokines, body weight, lean body mass, and improve quality of life.
UR - http://www.scopus.com/inward/record.url?scp=85046009848&partnerID=8YFLogxK
U2 - 10.1080/01635581.2018.1460678
DO - 10.1080/01635581.2018.1460678
M3 - Artículo
C2 - 29697274
SN - 0163-5581
VL - 70
SP - 663
EP - 670
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 4
ER -