Effect of caffeine coadministration and of nitric oxide synthesis inhibition on the antinociceptive action of ketorolac

Francisco J. López-Muñoz, Gilberto Castañeda-Hernández, Francisco J. Flores-Murrieta, Vinicio Granados-Soto

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of caffeine and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac were assessed using the pain-induced functional impairment model in the rat. Nociception was induced by the intra-articular injection of uric acid. Ketorolac, but not caffeine, produced an antinociceptive effect which was reduced by N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Caffeine coadministration potentiated the ketorolac effect. L-NAME induced a dose-dependent reduction of this potentiation. The results suggest the participation of the L-arginine-nitric oxide-cyclic GMP pathway in the caffeine potentiation of ketorolac-induced antinociception.
Original languageAmerican English
Pages (from-to)275-277
Number of pages247
JournalEuropean Journal of Pharmacology
DOIs
StatePublished - 25 Jul 1996
Externally publishedYes

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Ketorolac
Caffeine
NG-Nitroarginine Methyl Ester
Nitric Oxide
Intra-Articular Injections
Nociception
Cyclic GMP
Uric Acid
Arginine
Pain
Inhibition (Psychology)

Cite this

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title = "Effect of caffeine coadministration and of nitric oxide synthesis inhibition on the antinociceptive action of ketorolac",
abstract = "The effects of caffeine and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac were assessed using the pain-induced functional impairment model in the rat. Nociception was induced by the intra-articular injection of uric acid. Ketorolac, but not caffeine, produced an antinociceptive effect which was reduced by N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Caffeine coadministration potentiated the ketorolac effect. L-NAME induced a dose-dependent reduction of this potentiation. The results suggest the participation of the L-arginine-nitric oxide-cyclic GMP pathway in the caffeine potentiation of ketorolac-induced antinociception.",
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Effect of caffeine coadministration and of nitric oxide synthesis inhibition on the antinociceptive action of ketorolac. / López-Muñoz, Francisco J.; Castañeda-Hernández, Gilberto; Flores-Murrieta, Francisco J.; Granados-Soto, Vinicio.

In: European Journal of Pharmacology, 25.07.1996, p. 275-277.

Research output: Contribution to journalArticle

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AU - López-Muñoz, Francisco J.

AU - Castañeda-Hernández, Gilberto

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AU - Granados-Soto, Vinicio

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AB - The effects of caffeine and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac were assessed using the pain-induced functional impairment model in the rat. Nociception was induced by the intra-articular injection of uric acid. Ketorolac, but not caffeine, produced an antinociceptive effect which was reduced by N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Caffeine coadministration potentiated the ketorolac effect. L-NAME induced a dose-dependent reduction of this potentiation. The results suggest the participation of the L-arginine-nitric oxide-cyclic GMP pathway in the caffeine potentiation of ketorolac-induced antinociception.

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