TY - JOUR
T1 - Effect of caffeine coadministration and of nitric oxide synthesis inhibition on the antinociceptive action of ketorolac
AU - López-Muñoz, Francisco J.
AU - Castañeda-Hernández, Gilberto
AU - Flores-Murrieta, Francisco J.
AU - Granados-Soto, Vinicio
PY - 1996/7/25
Y1 - 1996/7/25
N2 - The effects of caffeine and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac were assessed using the pain-induced functional impairment model in the rat. Nociception was induced by the intra-articular injection of uric acid. Ketorolac, but not caffeine, produced an antinociceptive effect which was reduced by N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Caffeine coadministration potentiated the ketorolac effect. L-NAME induced a dose-dependent reduction of this potentiation. The results suggest the participation of the L-arginine-nitric oxide-cyclic GMP pathway in the caffeine potentiation of ketorolac-induced antinociception.
AB - The effects of caffeine and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac were assessed using the pain-induced functional impairment model in the rat. Nociception was induced by the intra-articular injection of uric acid. Ketorolac, but not caffeine, produced an antinociceptive effect which was reduced by N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis. Caffeine coadministration potentiated the ketorolac effect. L-NAME induced a dose-dependent reduction of this potentiation. The results suggest the participation of the L-arginine-nitric oxide-cyclic GMP pathway in the caffeine potentiation of ketorolac-induced antinociception.
KW - Antinociception
KW - Caffeine
KW - Ketorolac
KW - N(G)-Nitro-L-arginine methyl ester (L-NAME)
KW - Nitric oxide (NO)
KW - Potentiation
UR - http://www.scopus.com/inward/record.url?scp=0030601248&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(96)00320-2
DO - 10.1016/0014-2999(96)00320-2
M3 - Artículo
SN - 0014-2999
VL - 308
SP - 275
EP - 277
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -