TY - JOUR
T1 - Dynamic Infrared Thermography of Nanoheaters Embedded in Skin-Equivalent Phantoms
AU - López-Varela, K. A.
AU - Cayetano-Castro, N.
AU - Kolosovas-Machuca, E. S.
AU - González, F. J.
AU - Chiwo, F. S.
AU - Rodríguez-López, J. L.
N1 - Publisher Copyright:
© 2018 K. A. López-Varela et al.
PY - 2018
Y1 - 2018
N2 - Nanoheaters are promising tools for localized photothermal therapy (PTT) of malignant cells. The anisotropic AuNPs present tunable surface plasmon resonances (SPR) with ideal NIR optical response to be applied as theranostic agents. To this purpose, nanoparticles with branches are suitable because of the electromagnetic field concentrated at their vertices. We standardized a protocol to synthesize multibranched gold nanoparticles (MB-AuNPs) by the seed-growth method and found a size-seed dependence tunability on the hierarchy of branching. Once the optical response is evaluated, we tested the temporal stability as nanoheaters of the MB-AuNPs immersed in skin-equivalent phantoms by dynamic infrared thermography (DIRT). The most suited sample presents a concentration of 5.2×108 MB-AuNPs/mL showing good thermal stability with ΔT = 4.5°C, during 3 cycles of 10 min at 785 nm laser irradiation with power of 0.15 W. According to these results, the MB-AuNPs are suitable nanoheaters to be tested for PTT in more complex models.
AB - Nanoheaters are promising tools for localized photothermal therapy (PTT) of malignant cells. The anisotropic AuNPs present tunable surface plasmon resonances (SPR) with ideal NIR optical response to be applied as theranostic agents. To this purpose, nanoparticles with branches are suitable because of the electromagnetic field concentrated at their vertices. We standardized a protocol to synthesize multibranched gold nanoparticles (MB-AuNPs) by the seed-growth method and found a size-seed dependence tunability on the hierarchy of branching. Once the optical response is evaluated, we tested the temporal stability as nanoheaters of the MB-AuNPs immersed in skin-equivalent phantoms by dynamic infrared thermography (DIRT). The most suited sample presents a concentration of 5.2×108 MB-AuNPs/mL showing good thermal stability with ΔT = 4.5°C, during 3 cycles of 10 min at 785 nm laser irradiation with power of 0.15 W. According to these results, the MB-AuNPs are suitable nanoheaters to be tested for PTT in more complex models.
UR - http://www.scopus.com/inward/record.url?scp=85045918542&partnerID=8YFLogxK
U2 - 10.1155/2018/3847348
DO - 10.1155/2018/3847348
M3 - Artículo
SN - 1687-4110
VL - 2018
JO - Journal of Nanomaterials
JF - Journal of Nanomaterials
M1 - 3847348
ER -