Droperidol interactions with serotonergic and cardiovascular α adrenoceptors

Research output: Contribution to journalArticle

Abstract

The purpose of the present study was to determine whether the peripheral serotonergic receptors contribute to explain the cardiovascular effects of droperidol. The effects of droperidol on the presser or chronotropic responses elicited by continuous intravenous infusion of either noradrenaline (NA; 1 μg.kg-1.min-1), angiotensin II (1 μg.kg-1.min-1) on the serotonergic agonist quipazine (100 g.kg-1.min-1) were studied in pithed rats. Droperidol (0.01 μ to 1 mg.kg-1 i.v.) reversed the pressor effects of both NA or quipazine in a dose-related manner. Intravenous pretreatment with propranolol, brompheniramine or atropine (1 mg.kg-1; each) did not alter droperidol depressive effects. On the other hand, neither the pressure response to angiotensin II nor the chronotropic effects of pressor drugs were significantly affected by droperidol. In other experiments, similar hypotensive effects of droperidol ID50 141 μg/kg; CL 105-191) and the selective 5-HT2 blocker ketanserine (ID50 110 μg/kg; CL 91-132) on quipazine-induced pressor responses, were obtained; however, no significative change was observed with prazosin (α1-selective blocker). These results confirm that droperidol-induced hypotension can be attributed to its α-adrenergic blocking properties, and suggest a potential interaction of droperidol with serotonin at the level of vascular receptors.
Original languageAmerican English
Pages (from-to)109-114
Number of pages97
JournalRevista Mexicana de Anestesiologia
StatePublished - 1 Dec 1995

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Droperidol
Adrenergic Receptors
Rats
Quipazine
Experiments
Angiotensin II
Brompheniramine
induced response
Controlled Hypotension
Serotonin Receptor Agonists
effect
Prazosin
drug
Atropine
Intravenous Infusions
Propranolol
Adrenergic Agents
Blood Vessels
Serotonin
Norepinephrine

Cite this

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title = "Droperidol interactions with serotonergic and cardiovascular α adrenoceptors",
abstract = "The purpose of the present study was to determine whether the peripheral serotonergic receptors contribute to explain the cardiovascular effects of droperidol. The effects of droperidol on the presser or chronotropic responses elicited by continuous intravenous infusion of either noradrenaline (NA; 1 μg.kg-1.min-1), angiotensin II (1 μg.kg-1.min-1) on the serotonergic agonist quipazine (100 g.kg-1.min-1) were studied in pithed rats. Droperidol (0.01 μ to 1 mg.kg-1 i.v.) reversed the pressor effects of both NA or quipazine in a dose-related manner. Intravenous pretreatment with propranolol, brompheniramine or atropine (1 mg.kg-1; each) did not alter droperidol depressive effects. On the other hand, neither the pressure response to angiotensin II nor the chronotropic effects of pressor drugs were significantly affected by droperidol. In other experiments, similar hypotensive effects of droperidol ID50 141 μg/kg; CL 105-191) and the selective 5-HT2 blocker ketanserine (ID50 110 μg/kg; CL 91-132) on quipazine-induced pressor responses, were obtained; however, no significative change was observed with prazosin (α1-selective blocker). These results confirm that droperidol-induced hypotension can be attributed to its α-adrenergic blocking properties, and suggest a potential interaction of droperidol with serotonin at the level of vascular receptors.",
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Droperidol interactions with serotonergic and cardiovascular α adrenoceptors. / Bobadilla, R. A.; Castillo, E. F.; Valencia, I.; Castillo, C.; Hong, E.

In: Revista Mexicana de Anestesiologia, 01.12.1995, p. 109-114.

Research output: Contribution to journalArticle

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