TY - JOUR
T1 - Dominant lethal study of α-asarone in male and female mice after sub-chronic treatment
AU - Chamorro, Germán
AU - Salazar, Mariá
AU - Tamariz, Joaquín
AU - Díaz, Francisco
AU - Labarrios, Fernando
PY - 1999/6
Y1 - 1999/6
N2 - Dominant lethal studies were conducted in male and female mice with α-asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub-chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. α-Asarone did not produce germinal mutations in either males or females. Epididymal sperm examination of male mice immediately after treatment failed to reveal any alteration in sperm count on shape. No significant alterations were observed in testicular or epididymal weights or testicular histology.
AB - Dominant lethal studies were conducted in male and female mice with α-asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub-chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. α-Asarone did not produce germinal mutations in either males or females. Epididymal sperm examination of male mice immediately after treatment failed to reveal any alteration in sperm count on shape. No significant alterations were observed in testicular or epididymal weights or testicular histology.
KW - Asarone
KW - Dominant lethal study
KW - Genotoxicity
KW - Hypocholesterolaemic
KW - Hypolipidaemic
UR - http://www.scopus.com/inward/record.url?scp=0033058143&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1573(199906)13:4<308::AID-PTR449>3.0.CO;2-X
DO - 10.1002/(SICI)1099-1573(199906)13:4<308::AID-PTR449>3.0.CO;2-X
M3 - Artículo
SN - 0951-418X
VL - 13
SP - 308
EP - 311
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 4
ER -