Dominant lethal study of α-asarone in male and female mice after sub-chronic treatment

Germán Chamorro, Mariá Salazar, Joaquín Tamariz, Francisco Díaz, Fernando Labarrios

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9 Citations (Scopus)

Abstract

Dominant lethal studies were conducted in male and female mice with α-asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub-chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. α-Asarone did not produce germinal mutations in either males or females. Epididymal sperm examination of male mice immediately after treatment failed to reveal any alteration in sperm count on shape. No significant alterations were observed in testicular or epididymal weights or testicular histology.
Original languageAmerican English
Pages (from-to)308-311
Number of pages276
JournalPhytotherapy Research
DOIs
StatePublished - 1 Jun 1999

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Histology
Guatteria
Sperm Count
Spermatozoa
Therapeutics
Weights and Measures
Mutation
asarone

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Dominant lethal study of α-asarone in male and female mice after sub-chronic treatment. / Chamorro, Germán; Salazar, Mariá; Tamariz, Joaquín; Díaz, Francisco; Labarrios, Fernando.

In: Phytotherapy Research, 01.06.1999, p. 308-311.

Research output: Contribution to journalArticle

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