Diuretic activity of aqueous extract and smoothie preparation of verbesina crocata in rat

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Abstract

The aim of this study was to evaluate the diuretic activity of aqueous extract of Verbesina crocata at different doses in rat. The aqueous extract (100 and 400 mg/kg for decoction; 200 and 400 mg/kg for smoothie form), furosemide (4 mg/kg and vehicle were administered per os to rat. After 6 hours in metabolic cages, the urinary flow, glomerular filtration rate and electrolyte balance (Na+ and K+) were assessed. All doses produced an increment of urinary flow and Na+/K+ excretion. Glomerular filtration rate was incremented only on smoothie form at 400 mg/kg. These findings provide a basis explaining the traditional folk medicine use of this plant as a diuretic agent.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalBangladesh Journal of Pharmacology
Volume13
Issue number3
DOIs
StatePublished - 1 Jan 2018

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Verbesina
Traditional Medicine
Glomerular Filtration Rate
Diuretics
Water-Electrolyte Balance
Furosemide

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abstract = "The aim of this study was to evaluate the diuretic activity of aqueous extract of Verbesina crocata at different doses in rat. The aqueous extract (100 and 400 mg/kg for decoction; 200 and 400 mg/kg for smoothie form), furosemide (4 mg/kg and vehicle were administered per os to rat. After 6 hours in metabolic cages, the urinary flow, glomerular filtration rate and electrolyte balance (Na+ and K+) were assessed. All doses produced an increment of urinary flow and Na+/K+ excretion. Glomerular filtration rate was incremented only on smoothie form at 400 mg/kg. These findings provide a basis explaining the traditional folk medicine use of this plant as a diuretic agent.",
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AU - Salazar-Gómez, Anuar

AU - Pablo-Pérez, Saudy Saret

AU - Estévez-Carmona, María Mirian

AU - Meléndez-Camargo, María Estela

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AB - The aim of this study was to evaluate the diuretic activity of aqueous extract of Verbesina crocata at different doses in rat. The aqueous extract (100 and 400 mg/kg for decoction; 200 and 400 mg/kg for smoothie form), furosemide (4 mg/kg and vehicle were administered per os to rat. After 6 hours in metabolic cages, the urinary flow, glomerular filtration rate and electrolyte balance (Na+ and K+) were assessed. All doses produced an increment of urinary flow and Na+/K+ excretion. Glomerular filtration rate was incremented only on smoothie form at 400 mg/kg. These findings provide a basis explaining the traditional folk medicine use of this plant as a diuretic agent.

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