TY - JOUR
T1 - Diterpenes from seeds of Phalaris canariensis and their PTP1B inhibitory activity and hypoglycemic effects in streptozotocin-induced diabetic mice
AU - Perez Gutierrez, Rosa Martha
AU - Baez, Efren Garcia
N1 - Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/7/2
Y1 - 2020/7/2
N2 - This present study was to evaluate the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of nine diterpenes isolated from seeds of Phalaris canariensis, as well as their effect on streptozotocin-nicotinamide-induced type 2 diabetic mice. Their structures were established by spectroscopic analyses. Diterpenes, 1, 4, and 2 exhibited the strongest inhibitory activity on PTP1B with IC50 values of 6.9, 7.3, and 6.5 µM, respectively, The administration of 1-9 showed significant effect on hyperglycemia, among them 1, 4, and 2 reduced fasting glucose levels (55.65%, 54.27%, and 51.22%, respectively). Results revealed that diterpenes performed potential antidiabetic activity via inhibition of PTP1B. (Figure presented.).
AB - This present study was to evaluate the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of nine diterpenes isolated from seeds of Phalaris canariensis, as well as their effect on streptozotocin-nicotinamide-induced type 2 diabetic mice. Their structures were established by spectroscopic analyses. Diterpenes, 1, 4, and 2 exhibited the strongest inhibitory activity on PTP1B with IC50 values of 6.9, 7.3, and 6.5 µM, respectively, The administration of 1-9 showed significant effect on hyperglycemia, among them 1, 4, and 2 reduced fasting glucose levels (55.65%, 54.27%, and 51.22%, respectively). Results revealed that diterpenes performed potential antidiabetic activity via inhibition of PTP1B. (Figure presented.).
KW - Phalaris canariensis
KW - diterpenes
KW - hypoglycemic effect
KW - protein tyrosine phosphatase 1B
UR - http://www.scopus.com/inward/record.url?scp=85084783620&partnerID=8YFLogxK
U2 - 10.1080/10286020.2019.1636786
DO - 10.1080/10286020.2019.1636786
M3 - Artículo
C2 - 31322002
AN - SCOPUS:85084783620
SN - 1028-6020
VL - 22
SP - 603
EP - 617
JO - Journal of Asian Natural Products Research
JF - Journal of Asian Natural Products Research
IS - 7
ER -