Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast

C. A. González-Díaz, M. C. Uscanga-Carmona, C. D. Ibarra-Martínez, M. E. Jiménez-Fernández, L. M. Lozano-Trenado, J. G. Silva-Escobedo, S. M. Polo-Soto

Research output: Contribution to journalArticle

Abstract

Introduction.-Current limitations in the treatment of Breast Cancer (BC) are associated with late diagnosis of the disease. At present, there is no portable technology that allows a noninvasive diagnosis of early stage tumors in mammary gland. The electrical bioimpedance of neoplastic tissue is differentiable with respect to normal tissue. We have proposed bioimpedance measurements by Magnetic Induction Spectroscopy (MIS) as a noninvasive alternative to detect neoplasia in mammary gland. Objective.-To explore the feasibility of detecting neoplasia in mammary gland through MIS and to determine whether this technique allows the discrimination of BIRADS mammographic findings I vs II. Material and Methods.-Voluntary women with mammographic findings BIRADS I and II were monitored with an experimental portable inductive spectrometer to evaluate the influence of MIS in breast tissue in the bandwidth of 0.001 to 100 MHz. MIS measurements, body temperature and antroprometric values were compared by a parametric statistical test. Results.-Small differences in the inductive phase shift at frequencies below 100 kHz are evident between BIRADS groups. A mean value comparison of inductive phase shift at each frequency through a t-student test for independent samples showed statistically significant differences only at the frequency of 1.81 kHz. Discussion and Conclusion.-MIS measurements in breast tissue through the dielectric dispersion range below 100 kHz show technical feasibility to differentiate mamografical findings BIRADS I and II. Possible effects associated to temperature or instrumentation artifacts may confuse the MIS measurements. Extensive clinical studies of sensitivity and specificity to detect neoplasia in mammary gland are required to confirm the findings so far observed.
Original languageAmerican English
Pages (from-to)65-76
Number of pages57
JournalRevista Mexicana de Ingenieria Biomedica
StatePublished - 31 Dec 2012

Fingerprint

Electromagnetic induction
Spectrum Analysis
Breast
Spectroscopy
Human Mammary Glands
Tissue
Phase shift
Neoplasms
Statistical tests
Delayed Diagnosis
Body Temperature
Artifacts
Spectrometers
Tumors
Permittivity
Students
Breast Neoplasms
Technology
Bandwidth
Sensitivity and Specificity

Cite this

González-Díaz, C. A., Uscanga-Carmona, M. C., Ibarra-Martínez, C. D., Jiménez-Fernández, M. E., Lozano-Trenado, L. M., Silva-Escobedo, J. G., & Polo-Soto, S. M. (2012). Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast. Revista Mexicana de Ingenieria Biomedica, 65-76.
González-Díaz, C. A. ; Uscanga-Carmona, M. C. ; Ibarra-Martínez, C. D. ; Jiménez-Fernández, M. E. ; Lozano-Trenado, L. M. ; Silva-Escobedo, J. G. ; Polo-Soto, S. M. / Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast. In: Revista Mexicana de Ingenieria Biomedica. 2012 ; pp. 65-76.
@article{49c801ac56e64e21b5190101af6cb1b2,
title = "Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast",
abstract = "Introduction.-Current limitations in the treatment of Breast Cancer (BC) are associated with late diagnosis of the disease. At present, there is no portable technology that allows a noninvasive diagnosis of early stage tumors in mammary gland. The electrical bioimpedance of neoplastic tissue is differentiable with respect to normal tissue. We have proposed bioimpedance measurements by Magnetic Induction Spectroscopy (MIS) as a noninvasive alternative to detect neoplasia in mammary gland. Objective.-To explore the feasibility of detecting neoplasia in mammary gland through MIS and to determine whether this technique allows the discrimination of BIRADS mammographic findings I vs II. Material and Methods.-Voluntary women with mammographic findings BIRADS I and II were monitored with an experimental portable inductive spectrometer to evaluate the influence of MIS in breast tissue in the bandwidth of 0.001 to 100 MHz. MIS measurements, body temperature and antroprometric values were compared by a parametric statistical test. Results.-Small differences in the inductive phase shift at frequencies below 100 kHz are evident between BIRADS groups. A mean value comparison of inductive phase shift at each frequency through a t-student test for independent samples showed statistically significant differences only at the frequency of 1.81 kHz. Discussion and Conclusion.-MIS measurements in breast tissue through the dielectric dispersion range below 100 kHz show technical feasibility to differentiate mamografical findings BIRADS I and II. Possible effects associated to temperature or instrumentation artifacts may confuse the MIS measurements. Extensive clinical studies of sensitivity and specificity to detect neoplasia in mammary gland are required to confirm the findings so far observed.",
author = "Gonz{\'a}lez-D{\'i}az, {C. A.} and Uscanga-Carmona, {M. C.} and Ibarra-Mart{\'i}nez, {C. D.} and Jim{\'e}nez-Fern{\'a}ndez, {M. E.} and Lozano-Trenado, {L. M.} and Silva-Escobedo, {J. G.} and Polo-Soto, {S. M.}",
year = "2012",
month = "12",
day = "31",
language = "American English",
pages = "65--76",
journal = "Revista Mexicana de Ingenieria Biomedica",
issn = "0188-9532",
publisher = "Sociedad Mexicana de Ingenieria Biomedica",

}

González-Díaz, CA, Uscanga-Carmona, MC, Ibarra-Martínez, CD, Jiménez-Fernández, ME, Lozano-Trenado, LM, Silva-Escobedo, JG & Polo-Soto, SM 2012, 'Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast', Revista Mexicana de Ingenieria Biomedica, pp. 65-76.

Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast. / González-Díaz, C. A.; Uscanga-Carmona, M. C.; Ibarra-Martínez, C. D.; Jiménez-Fernández, M. E.; Lozano-Trenado, L. M.; Silva-Escobedo, J. G.; Polo-Soto, S. M.

In: Revista Mexicana de Ingenieria Biomedica, 31.12.2012, p. 65-76.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast

AU - González-Díaz, C. A.

AU - Uscanga-Carmona, M. C.

AU - Ibarra-Martínez, C. D.

AU - Jiménez-Fernández, M. E.

AU - Lozano-Trenado, L. M.

AU - Silva-Escobedo, J. G.

AU - Polo-Soto, S. M.

PY - 2012/12/31

Y1 - 2012/12/31

N2 - Introduction.-Current limitations in the treatment of Breast Cancer (BC) are associated with late diagnosis of the disease. At present, there is no portable technology that allows a noninvasive diagnosis of early stage tumors in mammary gland. The electrical bioimpedance of neoplastic tissue is differentiable with respect to normal tissue. We have proposed bioimpedance measurements by Magnetic Induction Spectroscopy (MIS) as a noninvasive alternative to detect neoplasia in mammary gland. Objective.-To explore the feasibility of detecting neoplasia in mammary gland through MIS and to determine whether this technique allows the discrimination of BIRADS mammographic findings I vs II. Material and Methods.-Voluntary women with mammographic findings BIRADS I and II were monitored with an experimental portable inductive spectrometer to evaluate the influence of MIS in breast tissue in the bandwidth of 0.001 to 100 MHz. MIS measurements, body temperature and antroprometric values were compared by a parametric statistical test. Results.-Small differences in the inductive phase shift at frequencies below 100 kHz are evident between BIRADS groups. A mean value comparison of inductive phase shift at each frequency through a t-student test for independent samples showed statistically significant differences only at the frequency of 1.81 kHz. Discussion and Conclusion.-MIS measurements in breast tissue through the dielectric dispersion range below 100 kHz show technical feasibility to differentiate mamografical findings BIRADS I and II. Possible effects associated to temperature or instrumentation artifacts may confuse the MIS measurements. Extensive clinical studies of sensitivity and specificity to detect neoplasia in mammary gland are required to confirm the findings so far observed.

AB - Introduction.-Current limitations in the treatment of Breast Cancer (BC) are associated with late diagnosis of the disease. At present, there is no portable technology that allows a noninvasive diagnosis of early stage tumors in mammary gland. The electrical bioimpedance of neoplastic tissue is differentiable with respect to normal tissue. We have proposed bioimpedance measurements by Magnetic Induction Spectroscopy (MIS) as a noninvasive alternative to detect neoplasia in mammary gland. Objective.-To explore the feasibility of detecting neoplasia in mammary gland through MIS and to determine whether this technique allows the discrimination of BIRADS mammographic findings I vs II. Material and Methods.-Voluntary women with mammographic findings BIRADS I and II were monitored with an experimental portable inductive spectrometer to evaluate the influence of MIS in breast tissue in the bandwidth of 0.001 to 100 MHz. MIS measurements, body temperature and antroprometric values were compared by a parametric statistical test. Results.-Small differences in the inductive phase shift at frequencies below 100 kHz are evident between BIRADS groups. A mean value comparison of inductive phase shift at each frequency through a t-student test for independent samples showed statistically significant differences only at the frequency of 1.81 kHz. Discussion and Conclusion.-MIS measurements in breast tissue through the dielectric dispersion range below 100 kHz show technical feasibility to differentiate mamografical findings BIRADS I and II. Possible effects associated to temperature or instrumentation artifacts may confuse the MIS measurements. Extensive clinical studies of sensitivity and specificity to detect neoplasia in mammary gland are required to confirm the findings so far observed.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875647298&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84875647298&origin=inward

M3 - Article

SP - 65

EP - 76

JO - Revista Mexicana de Ingenieria Biomedica

JF - Revista Mexicana de Ingenieria Biomedica

SN - 0188-9532

ER -

González-Díaz CA, Uscanga-Carmona MC, Ibarra-Martínez CD, Jiménez-Fernández ME, Lozano-Trenado LM, Silva-Escobedo JG et al. Differentiation BIRADS i vs II by magnetic induction spectroscopy: A potential innovative method to detect neoplasies in breast. Revista Mexicana de Ingenieria Biomedica. 2012 Dec 31;65-76.