TY - JOUR
T1 - Dietary compounds as epigenetic modulating agents in cancer
AU - Carlos-Reyes, Ángeles
AU - López-González, José Sullivan
AU - Meneses-Flores, Manuel
AU - Gallardo-Rincón, Dolores
AU - Ruíz-García, Erika
AU - Marchat, Laurence A.
AU - Astudillo-De La Vega, Horacio
AU - Hernández De La Cruz, Olga N.
AU - López-Camarillo, César
N1 - Publisher Copyright:
© 2019 Carlos-Reyes, López-González, Meneses-Flores, Gallardo-Rincón, Ruíz-García, Marchat, Astudillo-de la Vega, Hernández de la Cruz and López-Camarillo.
PY - 2019
Y1 - 2019
N2 - Epigenetic mechanisms control gene expression during normal development and their aberrant regulation may lead to human diseases including cancer. Natural phytochemicals can largely modulate mammalian epigenome through regulation of mechanisms and proteins responsible for chromatin remodeling. Phytochemicals are mainly contained in fruits, seeds, and vegetables as well as in foods supplements. These compounds act as powerful cellular antioxidants and anti-carcinogens agents. Several dietary compounds such as catechins, curcumin, genistein, quercetin and resveratrol, among others, exhibit potent anti-tumor activities through the reversion of epigenetic alterations associated to oncogenes activation and inactivation of tumor suppressor genes. In this review, we summarized the actual knowledge about the role of dietary phytochemicals in the restoration of aberrant epigenetic alterations found in cancer cells with a particular focus on DNA methylation and histone modifications. Furthermore, we discussed the mechanisms by which these natural compounds modulate gene expression at epigenetic level and described their molecular targets in diverse types of cancer. Modulation of epigenetic activities by phytochemicals will allow the discovery of novel biomarkers for cancer prevention, and highlights its potential as an alternative therapeutic approach in cancer.
AB - Epigenetic mechanisms control gene expression during normal development and their aberrant regulation may lead to human diseases including cancer. Natural phytochemicals can largely modulate mammalian epigenome through regulation of mechanisms and proteins responsible for chromatin remodeling. Phytochemicals are mainly contained in fruits, seeds, and vegetables as well as in foods supplements. These compounds act as powerful cellular antioxidants and anti-carcinogens agents. Several dietary compounds such as catechins, curcumin, genistein, quercetin and resveratrol, among others, exhibit potent anti-tumor activities through the reversion of epigenetic alterations associated to oncogenes activation and inactivation of tumor suppressor genes. In this review, we summarized the actual knowledge about the role of dietary phytochemicals in the restoration of aberrant epigenetic alterations found in cancer cells with a particular focus on DNA methylation and histone modifications. Furthermore, we discussed the mechanisms by which these natural compounds modulate gene expression at epigenetic level and described their molecular targets in diverse types of cancer. Modulation of epigenetic activities by phytochemicals will allow the discovery of novel biomarkers for cancer prevention, and highlights its potential as an alternative therapeutic approach in cancer.
KW - Cancer therapy
KW - DNA methylation
KW - Epigenetic machinery
KW - Histones modifications
KW - Phytochemicals
UR - http://www.scopus.com/inward/record.url?scp=85066610881&partnerID=8YFLogxK
U2 - 10.3389/fgene.2019.00079
DO - 10.3389/fgene.2019.00079
M3 - Artículo de revisión
C2 - 30881375
SN - 1664-8021
VL - 10
JO - Frontiers in Genetics
JF - Frontiers in Genetics
IS - MAR
M1 - 79
ER -