TY - JOUR
T1 - Design and Synthesis of Imidazo[1,2-a]pyridines with Carboxamide Group Substitution and In silico Evaluation of their Interaction with a LuxR-type Quorum Sensing Receptor
AU - Reynoso Lara, Juan Emmanuel
AU - Salgado-Zamora, Héctor
AU - Bazin, Marc Antoine
AU - Campos-Aldrete, María Elena
AU - Marchand, Pascal
N1 - Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/5
Y1 - 2018/5
N2 - Quorum sensing, an important process of bacterial communication, is involved in the development of complex behavior and expression of virulence factors that become important due to its key role in infection process. In this manuscript, docking studies were used as a preliminary screening to identify main interactions between LuxR receptor (CviR) of Chromobacterium violaceum as model and N-acyl L-homoserine lactones. Thus, following this approach, a library of imidazo[1,2-a]pyridines bearing carboxamide and urea moieties was designed, evaluated on this in silico model previously validated, and synthesized to generate new potential quorum sensing inhibitors. The present article summarizes survey to develop these new molecules with potential biological activity, based on interaction analysis ligand-receptor.
AB - Quorum sensing, an important process of bacterial communication, is involved in the development of complex behavior and expression of virulence factors that become important due to its key role in infection process. In this manuscript, docking studies were used as a preliminary screening to identify main interactions between LuxR receptor (CviR) of Chromobacterium violaceum as model and N-acyl L-homoserine lactones. Thus, following this approach, a library of imidazo[1,2-a]pyridines bearing carboxamide and urea moieties was designed, evaluated on this in silico model previously validated, and synthesized to generate new potential quorum sensing inhibitors. The present article summarizes survey to develop these new molecules with potential biological activity, based on interaction analysis ligand-receptor.
UR - http://www.scopus.com/inward/record.url?scp=85044366521&partnerID=8YFLogxK
U2 - 10.1002/jhet.3140
DO - 10.1002/jhet.3140
M3 - Artículo
SN - 0022-152X
VL - 55
SP - 1101
EP - 1111
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 5
ER -