TY - JOUR
T1 - Dengue Virus Increases the Expression of TREM-1 and CD10 on Human Neutrophils
AU - Ruiz-Pacheco, Juan A.
AU - Muñoz-Medina, E. José
AU - Castillo-Díaz, Luis A.
AU - Chacón-Salinas, Rommel
AU - Escobar-Gutiérrez, Alejandro
N1 - Publisher Copyright:
© Mary Ann Liebert, Inc., publishers 2023.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Every year, dengue is responsible for 400 million infections worldwide. Inflammation is related to the development of severe forms of dengue. Neutrophils are a heterogeneous cell population with a key role in the immune response. During viral infection, neutrophils are mainly recruited to the infection site; however, their excessive activation is linked to deleterious results. During dengue infection, neutrophils are involved in the pathogenesis through neutrophils extracellular traps production, tumor necrosis factor-Alpha, and interleukin-8 secretion. However, other molecules regulate the neutrophil role during viral infection. TREM-1 is expressed on neutrophils and its activation is related to increased production of inflammatory mediators. CD10 is expressed on mature neutrophils and has been associated with the regulation of neutrophil migration and immunosuppression. However, the role of both molecules during viral infection is limited, particularly during dengue infection. Here, we report for the first time that DENV-2 can significantly increase TREM-1 and CD10 expression as well as sTREM-1 production in cultured human neutrophils. Furthermore, we observed that treatment with granulocyte-macrophage colony stimulating factor, a molecule mostly produced in severe cases of dengue, is capable of inducing the overexpression of TREM-1 and CD10 on human neutrophils. These results suggest the participation of neutrophil CD10 and TREM-1 in the pathogenesis of dengue infection.
AB - Every year, dengue is responsible for 400 million infections worldwide. Inflammation is related to the development of severe forms of dengue. Neutrophils are a heterogeneous cell population with a key role in the immune response. During viral infection, neutrophils are mainly recruited to the infection site; however, their excessive activation is linked to deleterious results. During dengue infection, neutrophils are involved in the pathogenesis through neutrophils extracellular traps production, tumor necrosis factor-Alpha, and interleukin-8 secretion. However, other molecules regulate the neutrophil role during viral infection. TREM-1 is expressed on neutrophils and its activation is related to increased production of inflammatory mediators. CD10 is expressed on mature neutrophils and has been associated with the regulation of neutrophil migration and immunosuppression. However, the role of both molecules during viral infection is limited, particularly during dengue infection. Here, we report for the first time that DENV-2 can significantly increase TREM-1 and CD10 expression as well as sTREM-1 production in cultured human neutrophils. Furthermore, we observed that treatment with granulocyte-macrophage colony stimulating factor, a molecule mostly produced in severe cases of dengue, is capable of inducing the overexpression of TREM-1 and CD10 on human neutrophils. These results suggest the participation of neutrophil CD10 and TREM-1 in the pathogenesis of dengue infection.
KW - CD10
KW - TREM-1
KW - sTREM-1 y Dengue Virus
UR - http://www.scopus.com/inward/record.url?scp=85152972836&partnerID=8YFLogxK
U2 - 10.1089/vim.2022.0124
DO - 10.1089/vim.2022.0124
M3 - Artículo
C2 - 36811498
AN - SCOPUS:85152972836
SN - 0882-8245
VL - 36
SP - 176
EP - 185
JO - Viral Immunology
JF - Viral Immunology
IS - 3
ER -