TY - JOUR
T1 - Decreased methylation profiles in the TNFA gene promoters in type 1 macrophages and in the IL17A and RORC gene promoters in Th17 lymphocytes have a causal association with non-atopic asthma caused by obesity
T2 - A hypothesis
AU - Leija-Martínez, José J.
AU - Huang, Fengyang
AU - Del-Río-Navarro, Blanca E.
AU - Sanchéz-Muñoz, Fausto
AU - Romero-Nava, Rodrigo
AU - Muñoz-Hernandez, Onofre
AU - Rodríguez-Cortés, Octavio
AU - Hall-Mondragon, Margareth S.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - Obesity is a serious public health problem worldwide and has been associated in epidemiological studies with a unique type of non-atopic asthma, although the causal association of asthma and obesity has certain criteria, such as the strength of association, consistency, specificity, temporality, biological gradient, coherence, analogy and experimentation; nevertheless, the biological plausibility of this association remains uncertain. Various mechanisms have been postulated, such as immunological, hormonal, mechanical, environmental, genetic and epigenetic mechanisms. Our hypothesis favours immunological mechanisms because some cytokines, such as tumour necrosis factor alpha (TNF-α) and interleukin (IL)-17A, are responsible for orchestrating low-grade systemic inflammation associated with obesity; however, these cytokines are regulated by epigenetic mechanisms, such as gene promoter methylation.
AB - Obesity is a serious public health problem worldwide and has been associated in epidemiological studies with a unique type of non-atopic asthma, although the causal association of asthma and obesity has certain criteria, such as the strength of association, consistency, specificity, temporality, biological gradient, coherence, analogy and experimentation; nevertheless, the biological plausibility of this association remains uncertain. Various mechanisms have been postulated, such as immunological, hormonal, mechanical, environmental, genetic and epigenetic mechanisms. Our hypothesis favours immunological mechanisms because some cytokines, such as tumour necrosis factor alpha (TNF-α) and interleukin (IL)-17A, are responsible for orchestrating low-grade systemic inflammation associated with obesity; however, these cytokines are regulated by epigenetic mechanisms, such as gene promoter methylation.
KW - IL-17A
KW - Methylation
KW - Non-atopic asthma
KW - Obesity
KW - RORC
KW - Tumour necrosis factor-alpha
UR - http://www.scopus.com/inward/record.url?scp=85076825429&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2019.109527
DO - 10.1016/j.mehy.2019.109527
M3 - Artículo
C2 - 31877441
AN - SCOPUS:85076825429
SN - 0306-9877
VL - 134
JO - Medical Hypotheses
JF - Medical Hypotheses
M1 - 109527
ER -