TY - JOUR
T1 - Decreased frequency of cutaneous dendritic cells in elderly subjects
AU - Flores-Langarica, A.
AU - Calderon-Amador, J.
AU - Becerril-Garcia, M.
AU - Estrada-Garcia, I.
AU - Limon-Flores, Y.
AU - Lacy-Niebla, R.
AU - Hoyjo-Tomoka, T.
AU - Vega-Memije, E.
AU - Granados, J.
AU - Dominguez-Soto, L.
AU - Flores-Romo, L.
PY - 2005/7
Y1 - 2005/7
N2 - Background: Dendritic cells (DC) in peripheral tissues, such as the Langerhans cells (LC) in skin, function as sentinels of the immune system to efficiently initiate immune responses. Methods/Data base: We examined the frequency and phenotype of LC in the skin of people older than 90 years, compared to middle-aged (43 years) adult subjects. Results/Conclusion: Using two LC-restricted markers in the skin (MHC-II and CD1a), we found that, compared to middle-aged adult subjects, the skin of elderly people had a marked reduction of epidermal LC. In contrast, neither middle-aged adult skin nor aged skin showed positivity for any of the three toll-like receptors (TLR) evaluated (TLR 3, 4, 6). Unexpectedly, and unlike average adult skin, the skin of elderly subjects was clearly positive for abundant lipid raft staining, apparently restricted to basal epidermis. Using epithelial sheets, this difference was more evident. The precise implications of this finding are yet unclear but it reveals a marked difference between LC from average adults and elderly people, which might have a functional impact on LCs and immunity.
AB - Background: Dendritic cells (DC) in peripheral tissues, such as the Langerhans cells (LC) in skin, function as sentinels of the immune system to efficiently initiate immune responses. Methods/Data base: We examined the frequency and phenotype of LC in the skin of people older than 90 years, compared to middle-aged (43 years) adult subjects. Results/Conclusion: Using two LC-restricted markers in the skin (MHC-II and CD1a), we found that, compared to middle-aged adult subjects, the skin of elderly people had a marked reduction of epidermal LC. In contrast, neither middle-aged adult skin nor aged skin showed positivity for any of the three toll-like receptors (TLR) evaluated (TLR 3, 4, 6). Unexpectedly, and unlike average adult skin, the skin of elderly subjects was clearly positive for abundant lipid raft staining, apparently restricted to basal epidermis. Using epithelial sheets, this difference was more evident. The precise implications of this finding are yet unclear but it reveals a marked difference between LC from average adults and elderly people, which might have a functional impact on LCs and immunity.
KW - Elderly
KW - Human
KW - Langerhans cells
KW - Lipid rafts
UR - http://www.scopus.com/inward/record.url?scp=22944450340&partnerID=8YFLogxK
U2 - 10.1027/0838-1925.17.4.152
DO - 10.1027/0838-1925.17.4.152
M3 - Artículo
SN - 0838-1925
VL - 17
SP - 152
EP - 155
JO - Allergy and Clinical Immunology International
JF - Allergy and Clinical Immunology International
IS - 4
ER -