Damage to Oral Mucosae Induced by Weekend Alcohol Consumption: The Role of Gender and Alcohol Concentration

Laura Ligia González-López, Ángel Morales-González, Alejandra Sosa-Gómez, Eduardo Osiris Madrigal-Santillán, Liliana Anguiano-Robledo, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Luis Delgado-Olivares, Carmen Valadez-Vega, César Esquivel-Chirino, Nancy Vargas-Mendoza, José A. Morales-González

Research output: Contribution to journalArticlepeer-review


The damage caused by chronic alcohol consumption is frequently reported, but the effects caused by weekend recreational consumption, which is much more frequent than even daily con-sumption, have not, to our knowledge, been reported. The metabolism of ethanol, once consumed, starts from the mouth, and the biotransformation process follows different routes. In this study, the effect of weekend alcohol consumption on the oral cavity was observed. Methods: Thirty male and female rats were divided into six groups (n = 5), with control groups (male/female) and groups administered with 5% and 40% ethanol solution ad libitum consumption 2 days a week for 3 months. After treatment, the animals were sacrificed, an incisional slice of the cheek and back of the tongue was obtained, and the tissues were processed according to the histological technique and routine staining (hematoxylin-eosin, H&E). Samples were observed using light microscopy. Results: Histo-logical changes were observed in samples of tongue and cheek mucosa including different levels of keratinization of the surface layer. Epithelial dysplasia, acanthosis, and chronic inflammation were also observed. The vascularization level also increased because of the ethanol-induced damage. The results were very similar between female and male groups. Conclusion: Weekend alcohol consumption for a period of 3 months causes oral-cavity tissue alterations that could contribute to tumor growth and the development of cancer in the oral cavity.

Original languageEnglish
Article number3464
JournalApplied Sciences (Switzerland)
Issue number7
StatePublished - 1 Apr 2022


  • alcohol
  • cheek mucosa
  • damage
  • histological changes
  • oral cavity
  • tongue
  • weekend consumption


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