Cytotoxic constituents from Daphnia pulex

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Abstract

Activity-guided fractionation of the methanol extract of Daphnia pulex (Leydig) using the MTT assay and P-388, A549, KB, and HT-29 cell lines permitted the isolation of four known glyceroglycolipid compounds: (2S)-1-O-(7Z,1OZ,13Z)- hexadecatrienoyl-2-O-(7Z,1OZ)-hexadecadienoyl-3-O-β-D-galactopyranosyl-sn- glycerol, (2S)-1-O-(7Z,10Z)-hexadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O- β-D-galactopyranosyl-sn-glycerol, (2S)-1-O-(7Z,10Z)-hexadecadienolyl-2-O- linolenoyl-3-O-β-D-galactopyranosyl-sn-glycerol, and (2S)-1-O-(9Z, 12Z)-octadecadienoyl-2-O-(1Z,10Z)-hexadecadienoyl-3-O-(α-D- galactopyranosyl(1-6)-β-D-galactopyranosyl-sn-glycerol. All the isolates were found to be moderately cytotoxic (ED 50 < 4 μg/ml) toward P-388, A549, KB, and HT-29 cell lines. © 2005 Taylor & Francis Ltd.
Original languageAmerican English
Pages (from-to)313-316
Number of pages4
JournalPharmaceutical Biology
DOIs
StatePublished - 1 Jun 2005
Externally publishedYes

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Daphnia
HT29 Cells
Cell Line
Glycerol
Methanol
isofloridoside

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@article{a1931a677eb84e639fb7a029fa242d40,
title = "Cytotoxic constituents from Daphnia pulex",
abstract = "Activity-guided fractionation of the methanol extract of Daphnia pulex (Leydig) using the MTT assay and P-388, A549, KB, and HT-29 cell lines permitted the isolation of four known glyceroglycolipid compounds: (2S)-1-O-(7Z,1OZ,13Z)- hexadecatrienoyl-2-O-(7Z,1OZ)-hexadecadienoyl-3-O-β-D-galactopyranosyl-sn- glycerol, (2S)-1-O-(7Z,10Z)-hexadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O- β-D-galactopyranosyl-sn-glycerol, (2S)-1-O-(7Z,10Z)-hexadecadienolyl-2-O- linolenoyl-3-O-β-D-galactopyranosyl-sn-glycerol, and (2S)-1-O-(9Z, 12Z)-octadecadienoyl-2-O-(1Z,10Z)-hexadecadienoyl-3-O-(α-D- galactopyranosyl(1-6)-β-D-galactopyranosyl-sn-glycerol. All the isolates were found to be moderately cytotoxic (ED 50 < 4 μg/ml) toward P-388, A549, KB, and HT-29 cell lines. {\circledC} 2005 Taylor & Francis Ltd.",
author = "{P{\'e}rez Gutierrez}, {Rosa Martha} and {Lule P}, R.",
year = "2005",
month = "6",
day = "1",
doi = "10.1080/13880200590951702",
language = "American English",
pages = "313--316",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Taylor and Francis Ltd.",

}

Cytotoxic constituents from Daphnia pulex. / Pérez Gutierrez, Rosa Martha; Lule P, R.

In: Pharmaceutical Biology, 01.06.2005, p. 313-316.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

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AU - Pérez Gutierrez, Rosa Martha

AU - Lule P, R.

PY - 2005/6/1

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AB - Activity-guided fractionation of the methanol extract of Daphnia pulex (Leydig) using the MTT assay and P-388, A549, KB, and HT-29 cell lines permitted the isolation of four known glyceroglycolipid compounds: (2S)-1-O-(7Z,1OZ,13Z)- hexadecatrienoyl-2-O-(7Z,1OZ)-hexadecadienoyl-3-O-β-D-galactopyranosyl-sn- glycerol, (2S)-1-O-(7Z,10Z)-hexadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O- β-D-galactopyranosyl-sn-glycerol, (2S)-1-O-(7Z,10Z)-hexadecadienolyl-2-O- linolenoyl-3-O-β-D-galactopyranosyl-sn-glycerol, and (2S)-1-O-(9Z, 12Z)-octadecadienoyl-2-O-(1Z,10Z)-hexadecadienoyl-3-O-(α-D- galactopyranosyl(1-6)-β-D-galactopyranosyl-sn-glycerol. All the isolates were found to be moderately cytotoxic (ED 50 < 4 μg/ml) toward P-388, A549, KB, and HT-29 cell lines. © 2005 Taylor & Francis Ltd.

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