TY - JOUR
T1 - Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1,4-disubstituted 1,2,3-triazoles via click chemistry
AU - López-Ruiz, Heraclio
AU - De La Cerda-Pedro, José Emilio
AU - Rojas-Lima, Susana
AU - Pérez-Pérez, Imelda
AU - Rodríguez-Sánchez, Brianda Viridiana
AU - Santillan, Rosa
AU - Coreño, Oscar
PY - 2013/4/19
Y1 - 2013/4/19
N2 - Cuprous oxide on charcoal (Cu2O/C), the preparation of which is described for the first time, catalyzes the formation of 1,4-disubstituted 1,2,3-triazoles from organic azides and terminal alkynes in good to excellent yields (69-94%). These disubstituted triazoles can be equally efficiently generated in a one-pot process from alkyl bromides, sodium azide, and terminal acetylenes in 50% aqueous isopropanol containing a suspension of the catalyst. This obviates the necessity to isolate potentially explosive organic azides.
AB - Cuprous oxide on charcoal (Cu2O/C), the preparation of which is described for the first time, catalyzes the formation of 1,4-disubstituted 1,2,3-triazoles from organic azides and terminal alkynes in good to excellent yields (69-94%). These disubstituted triazoles can be equally efficiently generated in a one-pot process from alkyl bromides, sodium azide, and terminal acetylenes in 50% aqueous isopropanol containing a suspension of the catalyst. This obviates the necessity to isolate potentially explosive organic azides.
KW - 1,3-Dipolar cycloaddition
KW - Click chemistry
KW - Triazoles
UR - http://www.scopus.com/inward/record.url?scp=84877762705&partnerID=8YFLogxK
U2 - 10.3998/ark.5550190.0014.312
DO - 10.3998/ark.5550190.0014.312
M3 - Artículo
SN - 1551-7012
VL - 2013
SP - 139
EP - 164
JO - Arkivoc
JF - Arkivoc
IS - 3
ER -