CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes

Domingo Jiménez-López, Laura Aguilar-Henonin, Juan Manuel González-Prieto, Victor Aguilar-Hernández, Plinio Guzmán

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

© 2018 Jiménez-López et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. RING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to mechanism of action. Here we describe a new family of E3 ligases that encodes a RING-H2 domain related in sequence to the ATL and BTL RING-H2 domains. This family, named CTL, encodes a motif designed as YEELL that expands 21 amino acids next to the RING-H2 domain that is present across most eukaryotic lineages. E3 ubiquitin ligase BIG BROTHER is a plant CTL that regulates organ size, and SUMO-targeted ubiquitin E3 ligase RNF111/ARKADIA is a vertebrate CTL. Basal animal and vertebrate, as well as fungi species, encode a single CTL gene that constraints the number of paralogs observed in vertebrates. Conversely, as previously described in ATL and BTL families in plants, CTL genes range from a single copy in green algae and 3 to 5 copies in basal species to 9 to 35 copies in angiosperms. Our analysis describes key structural features of a novel family of E3 ubiquitin ligases as an integral component of the set of core eukaryotic genes.
Original languageAmerican English
JournalPLoS ONE
DOIs
StatePublished - 1 Jan 2018

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ubiquitin-protein ligase
Ubiquitin-Protein Ligases
Ligases
ubiquitin
Ubiquitin
Eukaryota
ligases
eukaryotic cells
vertebrates
Vertebrates
Genes
genes
new family
Angiosperms
Plant Genes
Chlorophyta
Organ Size
Angiospermae
mechanism of action
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Jiménez-López, Domingo ; Aguilar-Henonin, Laura ; González-Prieto, Juan Manuel ; Aguilar-Hernández, Victor ; Guzmán, Plinio. / CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes. In: PLoS ONE. 2018.
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CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the ring domain that is present across eukaryotes. / Jiménez-López, Domingo; Aguilar-Henonin, Laura; González-Prieto, Juan Manuel; Aguilar-Hernández, Victor; Guzmán, Plinio.

In: PLoS ONE, 01.01.2018.

Research output: Contribution to journalArticle

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