© 2015 Azael Torales-Cardeña et al. Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor "hypoxia-inducible factor 1-Alpha" (HIF-1) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1 in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.
Torales-Cardeña, A., Martínez-Torres, I., Rodríguez-Martínez, S., Gómez-Chávez, F., Cancino-Díaz, J. C., Vázquez-Sánchez, E. A., & Cancino-Díaz, M. E. (2015). Cross talk between proliferative, angiogenic, and cellular mechanisms orchestred by HIF-1 in Psoriasis. Mediators of inflammation. https://doi.org/10.1155/2015/607363