Cross-reaction, enhancement, and neutralization activity of dengue virus antibodies against zika virus: A study in the mexican population

Mayra R. Montecillo-Aguado, Alfredo E. Montes-Gómez, Julio García-Cordero, Josselin Corzo-Gómez, Héctor Vivanco-Cid, Gabriela Mellado-Sánchez, J. Esteban Muñoz-Medina, Benito Gutiérrez-Castañeda, Leopoldo Santos-Argumedo, César González-Bonilla, Leticia Cedillo-Barrón

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15 Scopus citations

Abstract

Copyright © 2019 Mayra R. Montecillo-Aguado et al. Zika virus (ZIKV), an emerging mosquito-borne flavivirus, has quickly spread in many regions around the world where dengue virus (DENV) is endemic. This represents a major health concern, given the high homology between these two viruses, which can result in cross-reactivity. The aim of this study was to determine the cross-reacting antibody response of the IgM and IgG classes against the recombinant envelope protein of ZIKV (rE-ZIKV) in sera from patients with acute-phase infection of different clinical forms of dengue, i.e., dengue fever (DF) and dengue hemorrhagic fever (DHF) (before the arrival of ZIKV in Mexico 2010), as well as acute-phase sera of ZIKV patients, together with the implications in neutralization and antibody-dependent enhancement. Differences in IgM responses were observed in a number of DF and DHF patients whose sera cross-reacted with the rE-ZIK antigen, with 42% recognition between acute-phase DHF and ZIKV but 27% recognition between DF and ZIKV. Regarding IgG antibodies, 71.5% from the DF group showed cross-reactivity to rE-ZIKV in contrast with 50% and only 25% of DHF and ZIKV serum samples, respectively, which specifically recognized the homologous antigen. The DHF group showed more enhancement of ZIKV infection of FCRã-expressing cells compared to the DF group. Furthermore, the DHF group also showed a higher cross-neutralizing ability than that of DF. This is the first report where DF and DHF serum samples were evaluated for cross-reactivity against Zika protein and ZIKV. Furthermore, DENV serum samples cross-protect against ZIKV through neutralizing antibodies but at the same time mediate antibody-dependent enhancement in the sequential ZIKV infection.
Original languageAmerican English
JournalJournal of Immunology Research
DOIs
StatePublished - 1 Jan 2019

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