Coyolosa, a new hypoglycemic from Acrocomia mexicana

Salud Pérez G, Rosa M. Pérez G, Cuauhtémoc Pérez G, Miguel A. Zavala S, Rosario Vargas S

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyrane derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg ip doses, and exhibited a dose-dependent response in the mice models.
Original languageAmerican English
Pages (from-to)105-111
Number of pages93
JournalPharmaceutica Acta Helvetiae
DOIs
StatePublished - 1 Apr 1997
Externally publishedYes

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Stereochemistry
Carbohydrates
Hypoglycemic Agents
Sugars
Spectrum analysis
Conformations
Methanol
Blood
Derivatives
Alloxan
Blood Glucose
coyolosa

Cite this

Pérez G, Salud ; Pérez G, Rosa M. ; Pérez G, Cuauhtémoc ; Zavala S, Miguel A. ; Vargas S, Rosario. / Coyolosa, a new hypoglycemic from Acrocomia mexicana. In: Pharmaceutica Acta Helvetiae. 1997 ; pp. 105-111.
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Coyolosa, a new hypoglycemic from Acrocomia mexicana. / Pérez G, Salud; Pérez G, Rosa M.; Pérez G, Cuauhtémoc; Zavala S, Miguel A.; Vargas S, Rosario.

In: Pharmaceutica Acta Helvetiae, 01.04.1997, p. 105-111.

Research output: Contribution to journalArticle

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