Coyolosa, a new hypoglycemic from Acrocomia mexicana

Salud Pérez G; Rosa M. Pérez G; Cuauhtémoc Pérez G; Miguel A. Zavala S; Rosario Vargas S

doi:10.1016/S0031-6865(96)00019-2

Coyolosa, a new hypoglycemic from Acrocomia mexicana

Salud Pérez G, Rosa M. Pérez G, Cuauhtémoc Pérez G, Miguel A. Zavala S, Rosario Vargas S

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyrane derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg ip doses, and exhibited a dose-dependent response in the mice models.

Original language	English
Pages (from-to)	105-111
Number of pages	7
Journal	Pharmaceutica Acta Helvetiae
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/S0031-6865(96)00019-2
State	Published - Apr 1997
Externally published	Yes

Keywords

1,2,3-Trihydroxy-4-(5,6-dihydroxyethylene)tetrahydrofurane
Acrocomia mexicana
Coyolosa
Hypoglycemic

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10.1016/S0031-6865(96)00019-2

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title = "Coyolosa, a new hypoglycemic from Acrocomia mexicana",

abstract = "From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyrane derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg ip doses, and exhibited a dose-dependent response in the mice models.",

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doi = "10.1016/S0031-6865(96)00019-2",

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journal = "Pharmaceutica Acta Helvetiae",

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T1 - Coyolosa, a new hypoglycemic from Acrocomia mexicana

AU - Pérez G, Salud

AU - Pérez G, Rosa M.

AU - Pérez G, Cuauhtémoc

AU - Zavala S, Miguel A.

AU - Vargas S, Rosario

PY - 1997/4

Y1 - 1997/4

N2 - From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyrane derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg ip doses, and exhibited a dose-dependent response in the mice models.

AB - From the methanol extract of the Arocomia mexicana root a new tetrahydropyrane compound was isolated. Its skeletal structure and relative stereochemistry were established by spectral analysis. Substituent effects have been determined with the hope of providing information about steric interactions and conformation of tetrahydropyrane derivatives and carbohydrates. The extract showed a significant blood sugar lowering effect on normal and alloxan-diabetic mice when administered at 2.5 to 40 mg/kg ip doses, and exhibited a dose-dependent response in the mice models.

KW - 1,2,3-Trihydroxy-4-(5,6-dihydroxyethylene)tetrahydrofurane

KW - Acrocomia mexicana

KW - Coyolosa

KW - Hypoglycemic

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DO - 10.1016/S0031-6865(96)00019-2

M3 - Artículo

SN - 0031-6865

VL - 72

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EP - 111

JO - Pharmaceutica Acta Helvetiae

JF - Pharmaceutica Acta Helvetiae

IS - 2

ER -

Coyolosa, a new hypoglycemic from Acrocomia mexicana

Abstract

Keywords

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