TY - JOUR
T1 - Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats
AU - Hernández-Saavedra, Diego
AU - Mendoza-Sánchez, Magdalena
AU - Hernández-Montiel, Hebert L.
AU - Guzmán-Maldonado, Horacio S.
AU - Loarca-Piña, Guadalupe F.
AU - Salgado, Luis M.
AU - Reynoso-Camacho, Rosalía
PY - 2013/6
Y1 - 2013/6
N2 - Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes.
AB - Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes.
KW - Bean
KW - Cytokines
KW - Diabetes
KW - Pancreatic damage
KW - Phenolic compounds
UR - http://www.scopus.com/inward/record.url?scp=84878012740&partnerID=8YFLogxK
U2 - 10.1007/s11130-013-0353-1
DO - 10.1007/s11130-013-0353-1
M3 - Artículo
C2 - 23595343
SN - 0921-9668
VL - 68
SP - 207
EP - 212
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
IS - 2
ER -