TY - JOUR
T1 - Control of AHPND by phages
T2 - a promising biotechnological approach
AU - Angulo, Carlos
AU - Loera-Muro, Abraham
AU - Trujillo, Edgar
AU - Luna-González, Antonio
N1 - Publisher Copyright:
© 2018 Wiley Publishing Asia Pty Ltd
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Vibrio parahaemolyticus, V. campbellii, V. owensii and V. harveyi are causative agents of Acute Hepatopancreatic Necrosis Disease (AHPND) in shrimp. AHPND is recently one of the most important diseases worldwide because of the high mortality and huge economic losses in shrimp farms. Antibiotic resistance has caused concern into finding other options to fight against pathogenic bacterial diseases. Currently, the use of lytic phages has reemerged as a promising strategy to combat bacterial pathogens. Likewise, modern molecular tools have been applied to modify phages by genetic engineering to express specific antigens and antibodies. This study reviewed recent research reports in the development of phages to control Vibrio spp. infections in shrimp and discusses different specific strategies, placing them in perspective to combat AHPND.
AB - Vibrio parahaemolyticus, V. campbellii, V. owensii and V. harveyi are causative agents of Acute Hepatopancreatic Necrosis Disease (AHPND) in shrimp. AHPND is recently one of the most important diseases worldwide because of the high mortality and huge economic losses in shrimp farms. Antibiotic resistance has caused concern into finding other options to fight against pathogenic bacterial diseases. Currently, the use of lytic phages has reemerged as a promising strategy to combat bacterial pathogens. Likewise, modern molecular tools have been applied to modify phages by genetic engineering to express specific antigens and antibodies. This study reviewed recent research reports in the development of phages to control Vibrio spp. infections in shrimp and discusses different specific strategies, placing them in perspective to combat AHPND.
KW - Vibrio spp.
KW - acute hepatopancreatic necrosis disease
KW - lytic phages
KW - phage therapy
KW - protein expression-based phages
KW - vibriosis
UR - http://www.scopus.com/inward/record.url?scp=85050473316&partnerID=8YFLogxK
U2 - 10.1111/raq.12275
DO - 10.1111/raq.12275
M3 - Artículo de revisión
SN - 1753-5123
VL - 11
SP - 989
EP - 1004
JO - Reviews in Aquaculture
JF - Reviews in Aquaculture
IS - 4
ER -