TY - JOUR
T1 - Contribution of APOA5, APOC3, CETP, ABCA1 and SIK3 genetic variants to hypertriglyceridemia development in Mexican HIV-patients receiving antiretroviral therapy
AU - Bautista-Martínez, Jonathan Saúl
AU - Mata-Marín, José Antonio
AU - Sandoval-Ramírez, Jorge Luis
AU - Chaparro-Sánchez, Alberto
AU - Manjarrez-Téllez, Bulmaro
AU - Uribe-Noguez, Luis Antonio
AU - Gaytán-Martínez, Jesús
AU - Núñez-Armendáriz, Mireya
AU - Cruz-Sánchez, Arcenio
AU - Núñez-Rodríguez, Nohemí
AU - Iván, Martínez Abarca
AU - Morales-González, Georgina Selene
AU - Álvarez-Mendoza, Juan Pablo
AU - Pérez-Barragán, Edgar
AU - Ríos-De Los Ríos, Jussara
AU - Contreras-Chávez, Gerson Gabriel
AU - Tapia-Magallanes, Denisse Marielle
AU - Ribas-Aparicio, Rosa Maria
AU - Díaz-López, Mónica
AU - Olivares-Labastida, Azucena
AU - Gómez-Delgado, Alejandro
AU - Torres, Javier
AU - Miranda-Duarte, Antonio
AU - Zenteno, Juan C.
AU - Pompa-Mera, Ericka Nelly
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Objective To investigate the impact of single nucleotide polymorphisms (SNPs) from APOA5, APOC3, CETP, ATP binding cassette transporter A1 and SIK3 genes in the development of hypertriglyceridemia in HIV patients under antiretroviral therapy. Material and Methods A case-control study was developed. Leukocytic genomic DNA was extracted and genotyping for SNPs rs662799, rs964184, rs5128, rs2854116, rs2854117, rs3764261, rs4149310, rs4149267 and rs139961185 was performed by real time-PCR using TaqMan allelic discrimination assays, in Mexican mestizo patients with HIV infection, with hypertriglyceridemia (>1.7 mmol/L) under antiretroviral therapy. Genetic variants were also investigated in a control group of normolipidemic HIV patients (≤ 1.7 mmol/L). Haplotypes and gene interactions were analyzed. Results A total of 602 HIV patients were genotyped (316 cases and 286 controls). Age and antiretroviral regimen based on protease inhibitors were associated with hypertriglyceridemia (P = 0.0001 and P = 0.0002. respectively). SNP rs964184 GG genotype in APOA5 gene exhibited the highest association with hypertriglyceridemia risk (OR, 3.2, 95% CI, 1.7-5.8, P = 0.0001); followed by SNP rs139961185 in SIK3 gene (OR = 2.3; (95% CI, 1.1-4.8; P = 0.03 for AA vs. AG genotype; and APOC3 rs5128 GG genotype, (OR, 2.2; 95% CI, 1.1-4.9; P = 0.04) under codominant models. These associations were maintained in the adjusted analysis by age and protease inhibitors based antiretroviral regimens. Conclusions This study reveals an association between rs964184 in APOA5; rs5128 in APOC3 and rs139961185 in SIK3 and high triglyceride concentrations in Mexican HIV-patients receiving protease inhibitors. These genetic factors may influence the adverse effects related to antiretroviral therapy.
AB - Objective To investigate the impact of single nucleotide polymorphisms (SNPs) from APOA5, APOC3, CETP, ATP binding cassette transporter A1 and SIK3 genes in the development of hypertriglyceridemia in HIV patients under antiretroviral therapy. Material and Methods A case-control study was developed. Leukocytic genomic DNA was extracted and genotyping for SNPs rs662799, rs964184, rs5128, rs2854116, rs2854117, rs3764261, rs4149310, rs4149267 and rs139961185 was performed by real time-PCR using TaqMan allelic discrimination assays, in Mexican mestizo patients with HIV infection, with hypertriglyceridemia (>1.7 mmol/L) under antiretroviral therapy. Genetic variants were also investigated in a control group of normolipidemic HIV patients (≤ 1.7 mmol/L). Haplotypes and gene interactions were analyzed. Results A total of 602 HIV patients were genotyped (316 cases and 286 controls). Age and antiretroviral regimen based on protease inhibitors were associated with hypertriglyceridemia (P = 0.0001 and P = 0.0002. respectively). SNP rs964184 GG genotype in APOA5 gene exhibited the highest association with hypertriglyceridemia risk (OR, 3.2, 95% CI, 1.7-5.8, P = 0.0001); followed by SNP rs139961185 in SIK3 gene (OR = 2.3; (95% CI, 1.1-4.8; P = 0.03 for AA vs. AG genotype; and APOC3 rs5128 GG genotype, (OR, 2.2; 95% CI, 1.1-4.9; P = 0.04) under codominant models. These associations were maintained in the adjusted analysis by age and protease inhibitors based antiretroviral regimens. Conclusions This study reveals an association between rs964184 in APOA5; rs5128 in APOC3 and rs139961185 in SIK3 and high triglyceride concentrations in Mexican HIV-patients receiving protease inhibitors. These genetic factors may influence the adverse effects related to antiretroviral therapy.
KW - CETP
KW - HIV infection
KW - Salt-inducible kinase 3
KW - apolipoprotein A5
KW - apolipoprotein C3
KW - hypertriglyceridemia
KW - single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=85128159911&partnerID=8YFLogxK
U2 - 10.1097/FPC.0000000000000458
DO - 10.1097/FPC.0000000000000458
M3 - Artículo
C2 - 34693928
AN - SCOPUS:85128159911
SN - 1744-6872
VL - 32
SP - 101
EP - 110
JO - Pharmacogenetics and Genomics
JF - Pharmacogenetics and Genomics
IS - 3
ER -