TY - JOUR
T1 - Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue
AU - Rabadan-Chávez, Griselda
AU - Quevedo-Corona, Lucia
AU - Garcia, Angel Miliar
AU - Reyes-Maldonado, Elba
AU - Jaramillo-Flores, María Eugenia
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Cocoa flavan-3-ols have been shown to exert a positive influence on obesity-related metabolic risk factors. This study evaluated the effects of cocoa powder (Co), cocoa extract (Co-Ex) and its main flavanols (Epi, Cat and PB2) on the expression of genes involved in WAT lipid metabolism in a rat model of hypercaloric diet-induced obesity. Co, Co-Ex and Epi are associated with adipogenesis, β-oxidation and energy expenditure in WAT linked to upregulating the expression of peroxisome-proliferator-activated receptor γ (PPARγ), PPARα, PPARγ coactivator 1α (PGC1α), sirtuin 1 (SIRT1) and uncoupling protein 1 (UCP1). Additionally, these treatments are associated with decreases in body weight gain and total fat mass and insulin resistance, reduced lipogenesis, and inflammation related to downregulating acetyl-CoA carboxylase gene expression, decreasing TNF-α and increasing ApN concentrations in WAT. Co, Co-Ex and Epi may be considered to be potential agents for the treatment of obesity-related metabolic disorders.
AB - Cocoa flavan-3-ols have been shown to exert a positive influence on obesity-related metabolic risk factors. This study evaluated the effects of cocoa powder (Co), cocoa extract (Co-Ex) and its main flavanols (Epi, Cat and PB2) on the expression of genes involved in WAT lipid metabolism in a rat model of hypercaloric diet-induced obesity. Co, Co-Ex and Epi are associated with adipogenesis, β-oxidation and energy expenditure in WAT linked to upregulating the expression of peroxisome-proliferator-activated receptor γ (PPARγ), PPARα, PPARγ coactivator 1α (PGC1α), sirtuin 1 (SIRT1) and uncoupling protein 1 (UCP1). Additionally, these treatments are associated with decreases in body weight gain and total fat mass and insulin resistance, reduced lipogenesis, and inflammation related to downregulating acetyl-CoA carboxylase gene expression, decreasing TNF-α and increasing ApN concentrations in WAT. Co, Co-Ex and Epi may be considered to be potential agents for the treatment of obesity-related metabolic disorders.
KW - Cocoa extract
KW - Cocoa powder
KW - Energy expenditure
KW - Epicatechin
KW - Obesity
KW - β-oxidation
UR - http://www.scopus.com/inward/record.url?scp=84953410733&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2015.10.016
DO - 10.1016/j.jff.2015.10.016
M3 - Artículo
SN - 1756-4646
VL - 20
SP - 54
EP - 67
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -