TY - JOUR
T1 - Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19
AU - Martinez-Cuazitl, Adriana
AU - Mata-Miranda, Monica M.
AU - Sanchez-Brito, Miguel
AU - Valencia-Trujillo, Daniel
AU - Avila-Trejo, Amanda M.
AU - Delgado-Macuil, Raul J.
AU - Atriano-Colorado, Consuelo
AU - Garibay-Gonzalez, Francisco
AU - Sanchez-Monroy, Virginia
AU - Vazquez-Zapien, Gustavo J.
N1 - Publisher Copyright:
© 2023 Adriana Martinez-Cuazitl et al.
PY - 2023
Y1 - 2023
N2 - The wide range of symptoms of the coronavirus disease 2019 (COVID-19) makes it challenging to predict the disease evolution using a single parameter. Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to survival or death, the sociodemographic and clinical characteristics, the biochemical and immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples and their correlation with chemometric findings. Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. Moreover, humoral (IgM) and cellular (IFN-γ, TNF-α, IL-10, and IL-6) responses were also increased in patients who died from COVID-19.
AB - The wide range of symptoms of the coronavirus disease 2019 (COVID-19) makes it challenging to predict the disease evolution using a single parameter. Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to survival or death, the sociodemographic and clinical characteristics, the biochemical and immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples and their correlation with chemometric findings. Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. Moreover, humoral (IgM) and cellular (IFN-γ, TNF-α, IL-10, and IL-6) responses were also increased in patients who died from COVID-19.
UR - http://www.scopus.com/inward/record.url?scp=85150484300&partnerID=8YFLogxK
U2 - 10.1155/2023/3423183
DO - 10.1155/2023/3423183
M3 - Artículo
AN - SCOPUS:85150484300
SN - 2314-4920
VL - 2023
JO - Journal of Spectroscopy
JF - Journal of Spectroscopy
M1 - 3423183
ER -