CLICK CHEMISTRY TOWARD THE SYNTHESIS OF ANTICANCER AGENTS

Ashutosh Pal; Bimal Krishna Banik

doi:10.3987/REV-21-970

CLICK CHEMISTRY TOWARD THE SYNTHESIS OF ANTICANCER AGENTS

Ashutosh Pal, Bimal Krishna Banik

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The copper(I)-induced synthesis of 1,2,3-triazoles using azides and alkynes (click chemistry) has become extremely significant. Click chemistry has been used in all aspects of drug discovery research. The product triazole serves as a linker as it readily combines with targets through hydrogen-bonding and dipole interaction. This review summarizes the application of click chemistry and triazoles as anticancer drugs. These types of reactions proceed with high selectivity, specificity, and yields. A variety of complex molecules are synthesized by this method.

Original language	English
Pages (from-to)	229-266
Number of pages	38
Journal	Heterocycles
Volume	104
Issue number	2
DOIs	https://doi.org/10.3987/REV-21-970
State	Published - 2022
Externally published	Yes

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abstract = "The copper(I)-induced synthesis of 1,2,3-triazoles using azides and alkynes (click chemistry) has become extremely significant. Click chemistry has been used in all aspects of drug discovery research. The product triazole serves as a linker as it readily combines with targets through hydrogen-bonding and dipole interaction. This review summarizes the application of click chemistry and triazoles as anticancer drugs. These types of reactions proceed with high selectivity, specificity, and yields. A variety of complex molecules are synthesized by this method.",

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AB - The copper(I)-induced synthesis of 1,2,3-triazoles using azides and alkynes (click chemistry) has become extremely significant. Click chemistry has been used in all aspects of drug discovery research. The product triazole serves as a linker as it readily combines with targets through hydrogen-bonding and dipole interaction. This review summarizes the application of click chemistry and triazoles as anticancer drugs. These types of reactions proceed with high selectivity, specificity, and yields. A variety of complex molecules are synthesized by this method.

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CLICK CHEMISTRY TOWARD THE SYNTHESIS OF ANTICANCER AGENTS

Abstract

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