Chemopreventive and antioxidant effect of polyphenol free Spirulina maxima and its hydrolyzed protein content: Investigation on azoxymethane treated mice

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Spirulina maxima (Sm) is known to have nutritive value as well as a number of potentially useful biomedical properties. Objectives: The initial purpose of this report was to evaluate the inhibitory effect of the alga (without its polyphenol content), on the induction of azoxymethane (AOM)-induced colon aberrant crypts (AC) in mouse. Besides, we hydrolyzed the protein content of such mixture. Our second aim was to determine the inhibitory potential of this last plant mixture on the AOM-induced colon AC in mouse. Moreover, we also determined the effect of the two indicated Sm samples on the oxidative damage caused by AOM in the colon and liver of treated mice. Materials and Methods: The experiment lasted 5 weeks. At the end, we registered the level of AC, nitric oxide, and the lipid and protein oxidation. Results: Our results showed the following: (1) the carcinogen increased more than 18 times the amount of the AC found in the control group. (2) On the contrary, the two tested mixtures of Sm produced a significant reduction over this damage (about 45%). (3) The two tested Sm mixtures were generally able to reduce the oxidative stress markers although with variable effects which go from 59% to 100% with respect to the control mice. Conclusion: Therefore, the present report established that the tested Sm fractions have mouse colon anticarcinogenic potential, partially related with their antioxidant capacity. Our report also suggested the need to further evaluate specific Sm chemicals as chemopreventive agents.

Original languageEnglish
Pages (from-to)S164-S169
JournalPharmacognosy Magazine
Volume13
Issue number50
DOIs
StatePublished - 1 Apr 2017

Keywords

  • Antioxidation
  • Chemoprevention
  • Mouse
  • Spirulina maxima fractions

Fingerprint

Dive into the research topics of 'Chemopreventive and antioxidant effect of polyphenol free Spirulina maxima and its hydrolyzed protein content: Investigation on azoxymethane treated mice'. Together they form a unique fingerprint.

Cite this