Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico

Ronna Delgado-Altamirano, Rosa Isela López-Palma, Lianet Monzote, José Delgado-Domínguez, Ingeborg Becker, José Fausto Rivero-Cruz, Nuria Esturau-Escofet, Pedro A. Vázquez-Landaverde, Alejandra Rojas-Molina

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13 Scopus citations

Abstract

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC 50 ) = 12.02 ± 0.36 µM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

Original languageEnglish
Article number872
JournalInternational Journal of Molecular Sciences
Volume20
Issue number4
DOIs
StatePublished - 2 Feb 2019
Externally publishedYes

Keywords

  • Bio-directed fractionation
  • Camaric acid
  • Lantadene b
  • Lantana camara
  • Lantanilic acid
  • Leishmania amazonensis
  • Leishmania mexicana
  • Leishmanicidal activity
  • Triterpenes

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