Characterization of the calcium influx in human omental vessels of patients with advanced chronic kidney disease

Cruz Domínguez Maria del Pilar, Maria de los Angeles Martinez-Godinez, Montes Cortés Daniel, Ortiz Villegas Miguel, Guevara Balcazar Gustavo, Vera Arzave Carlos, Castillo Hernández Maria del Carmen

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic Kidney Disease (CKD) has a high morbimortality at a global level and alone is a cardiovascular risk factor because of its predisposition to anemia, acid base balance, and hydroelectrolytic and bone mineral metabolism disorders, the ones related to anemia or volume overload. These changes lead to morphofunctional changes and modification in the calcium reactivity at a cardiovascular level. The main purpose of this paper is to analyze morphofunctional changes associated to the influx of calcium in the omental vessels of patients with CKD. Histopathological and functional changes of the omental arteries of patients with CKD were assessed. The results obtained showed an increase in the vascular wall in the group with CKD with respect to control and CKD-DM. The contractile response to calcium is lower in the arteries of patients with CKD with respect to controls and on the other hand the capacitative calcium influx is higher in arteries of patients with CKD and CKD-DM. Therefore, it was observed that there is a modification both in morphological and calcium reactivity in the omental arteries of patients with CKD, which are associated with cardiovascular disorders in these patients.

Original languageEnglish
Pages (from-to)3769-3773
Number of pages5
JournalBiomedical Research (India)
Volume28
Issue number8
StatePublished - 2017

Keywords

  • Calcium
  • Chronic kidney disease
  • Diabetes mellitus
  • Omental vessels

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