TY - JOUR
T1 - Characterization of the calcium influx in human omental vessels of patients with advanced chronic kidney disease
AU - del Pilar, Cruz Domínguez Maria
AU - Martinez-Godinez, Maria de los Angeles
AU - Daniel, Montes Cortés
AU - Miguel, Ortiz Villegas
AU - Gustavo, Guevara Balcazar
AU - Carlos, Vera Arzave
AU - del Carmen, Castillo Hernández Maria
N1 - Publisher Copyright:
© 2017, Scientific Publishers of India. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Chronic Kidney Disease (CKD) has a high morbimortality at a global level and alone is a cardiovascular risk factor because of its predisposition to anemia, acid base balance, and hydroelectrolytic and bone mineral metabolism disorders, the ones related to anemia or volume overload. These changes lead to morphofunctional changes and modification in the calcium reactivity at a cardiovascular level. The main purpose of this paper is to analyze morphofunctional changes associated to the influx of calcium in the omental vessels of patients with CKD. Histopathological and functional changes of the omental arteries of patients with CKD were assessed. The results obtained showed an increase in the vascular wall in the group with CKD with respect to control and CKD-DM. The contractile response to calcium is lower in the arteries of patients with CKD with respect to controls and on the other hand the capacitative calcium influx is higher in arteries of patients with CKD and CKD-DM. Therefore, it was observed that there is a modification both in morphological and calcium reactivity in the omental arteries of patients with CKD, which are associated with cardiovascular disorders in these patients.
AB - Chronic Kidney Disease (CKD) has a high morbimortality at a global level and alone is a cardiovascular risk factor because of its predisposition to anemia, acid base balance, and hydroelectrolytic and bone mineral metabolism disorders, the ones related to anemia or volume overload. These changes lead to morphofunctional changes and modification in the calcium reactivity at a cardiovascular level. The main purpose of this paper is to analyze morphofunctional changes associated to the influx of calcium in the omental vessels of patients with CKD. Histopathological and functional changes of the omental arteries of patients with CKD were assessed. The results obtained showed an increase in the vascular wall in the group with CKD with respect to control and CKD-DM. The contractile response to calcium is lower in the arteries of patients with CKD with respect to controls and on the other hand the capacitative calcium influx is higher in arteries of patients with CKD and CKD-DM. Therefore, it was observed that there is a modification both in morphological and calcium reactivity in the omental arteries of patients with CKD, which are associated with cardiovascular disorders in these patients.
KW - Calcium
KW - Chronic kidney disease
KW - Diabetes mellitus
KW - Omental vessels
UR - http://www.scopus.com/inward/record.url?scp=85019629552&partnerID=8YFLogxK
M3 - Artículo
SN - 0970-938X
VL - 28
SP - 3769
EP - 3773
JO - Biomedical Research (India)
JF - Biomedical Research (India)
IS - 8
ER -