CDK4 as a phytochemical based anticancer drug target

M. Arif Ashraf, Shomoita Sayed, Martiniano Bello, Nazmul Hussain, Rony Kumer Chando, Saruar Alam, Md Kamrul Hasan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The success story of plant-based medicine has been overlooked during the advent of the modern pharmaceutical industry. Despite the negligence of the multibillion-dollar drug industry, people entirely rely on medicinal plants in some parts of the world. In this study, we have emphasized going back to those traditional medicinal practices to determine their underlying mechanism to move forward on phytochemical-based drug development. We screened Medicinal Plant Database Bangladesh (MPDB2.0) to find traditionally used medicinal plants and their active compounds. Here, mangiferin, extracted from Mangifera indica, has interacted with cell cycle regulator Cyclin-dependent Kinase 4 (CDK4). CDK4 is differentially expressed during Glioblastoma multiforme (GBM), Brain Lower Grade Glioma (LGG), and Sarcoma (SARC). Expression of CDK4 is interlinked to the patients’ survival rate and its consistent expression throughout different stages has provided the advantage to use it as a diagnostic tool and drug target. This study demonstrated that a simple mango tree extracted active compound ‘mangiferin’ may work as a potential anticancer drug, and leveraging the recent advancement of sequencing and gene expression data can accelerate the phytochemical-based drug discovery process.

Original languageEnglish
Article number100826
JournalInformatics in Medicine Unlocked
Volume28
DOIs
StatePublished - Jan 2022

Keywords

  • Anticancer drug
  • CDK-4
  • MPDB2.0
  • Mangiferin
  • Medicinal plant
  • Phytochemical based drug discovery

Fingerprint

Dive into the research topics of 'CDK4 as a phytochemical based anticancer drug target'. Together they form a unique fingerprint.

Cite this