TY - JOUR
T1 - Catechins modulate the activity of mu opioid receptor (μOR)
T2 - An in silico approach
AU - Ortiz-Flores, Miguel
AU - Portilla-Martínez, Andrés
AU - González-Ruiz, Cristian
AU - Villarreal, Francisco
AU - Meaney, Eduardo
AU - Nájera, Nayelli
AU - Ceballos, Guillermo
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020
Y1 - 2020
N2 - Treating addiction and withdrawal syndrome remains a research area of great interest since it is a persistent public health problem. Opiates account for the majority of addiction and withdrawal problems (at least 56% of reported people who consume drugs). Development of opiate addiction results mainly from activation of the mu-opioid receptor (MOR), and this entity is identified as a major target for the treatment of addiction and withdrawal syndrome. Based on our in silico analysis and calculations of binding energy, conformations adopted by catechins and contacts reached by ligand conformations could explain why opiates are capable of activating both β-arrestin and G-protein biased pathways, and therefore help to explain the phenomenon of tolerance, we can conclude that the family of catechins explored seem to be excellent modulators of the MOR.
AB - Treating addiction and withdrawal syndrome remains a research area of great interest since it is a persistent public health problem. Opiates account for the majority of addiction and withdrawal problems (at least 56% of reported people who consume drugs). Development of opiate addiction results mainly from activation of the mu-opioid receptor (MOR), and this entity is identified as a major target for the treatment of addiction and withdrawal syndrome. Based on our in silico analysis and calculations of binding energy, conformations adopted by catechins and contacts reached by ligand conformations could explain why opiates are capable of activating both β-arrestin and G-protein biased pathways, and therefore help to explain the phenomenon of tolerance, we can conclude that the family of catechins explored seem to be excellent modulators of the MOR.
KW - Abuse
KW - Antagonism
KW - Catechins
KW - Opioid receptors
UR - http://www.scopus.com/inward/record.url?scp=85091778017&partnerID=8YFLogxK
U2 - 10.1016/j.imu.2020.100431
DO - 10.1016/j.imu.2020.100431
M3 - Artículo
AN - SCOPUS:85091778017
SN - 2352-9148
VL - 20
JO - Informatics in Medicine Unlocked
JF - Informatics in Medicine Unlocked
M1 - 100431
ER -