Case report: Extrapulmonary manifestations of COVID-19 and dengue coinfection

José Manuel Reyes-Ruiz, Rosa Campuzano-Vences, Juan Fidel Osuna-Ramos, Luis Adrián de Jesus-González, María J. Pérez-Méndez, Crescencio González-González, Carlos Noe Farfan-Morales, Leticia Rivas-Tovar, Eduardo Davila-González, Rosa María del Ángel, Aarón P. Gutiérrez-Garduño, Enrique Villegas-Del Ángel, Paola Zárate-Segura, Fernando Bastida-González

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The risk of coronavirus disease 2019 (COVID-19) and dengue coinfection is increased in tropical countries; however, the extrapulmonary clinical manifestations have not been fully characterized. We report a 42-year-old woman whose clinical manifestations began with fever, diarrhea, headache, chest pain, myalgia, odynophagia, and arthralgia. Despite mild respiratory symptoms and normal chest computed tomography scan results, she was diagnosed with real-time reverse-transcription polymerase chain reaction (RT-PCR)-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because she had erythema and petechiae with a decreased platelet count, the dengue NS1 antigen and anti-dengue IgM/IgG test were performed, and the Centers for Disease Control and Prevention RT-PCR assay detected the dengue virus serotype 1 infection. Additionally, increased liver enzyme serum levels were found in the patient, who later developed hepatomegaly. Hence, the mechanism of hepatic pathology associated with SARS-CoV-2 and dengue coinfection needs further research.

Original languageEnglish
Pages (from-to)363-397
Number of pages35
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number2
StatePublished - Aug 2021


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