Cardiac amyloidosis, constrictive pericarditis and restrictive cardiomyopathy

Eduardo Meaney, Ralph Shabetai, Valmik Bhargava, Mary Shearer, Cathy Weidner, Lucia Maria Mangiardi, Richard Smalling, Kirk Peterson

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Cardiac amyloidosis is not characterized by a single hemodynamic pattern. Some of the cases present the clinical findings of restrictive cardiomyopathy and in these differentiation from constrictive pericarditis remains difficult in spite of the introduction of techniques designed to assess myocardial contractility and ventricular diastolic compliance. The clinical features and the demonstration of left ventricular diastolic pressure greater than right remain the most useful means of distinguishing restrictive cardiomyopathy from constrictive pericarditis. In other cases of cardiac amyloidosis the diastolic pressure is elevated throughout diastole and ventricular ejectile ability is lost. These cases do not simulate constrictive pericarditis and should not be classified as restrictive cardiomyopathy.

Original languageEnglish
Pages (from-to)547-556
Number of pages10
JournalThe American Journal of Cardiology
Issue number5
StatePublished - 4 Nov 1976
Externally publishedYes


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